c-myc Affinity Purified Antibody, FITC Conjugated | MyBioSource MBS194206 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

c-myc Affinity Purified Antibody, FITC Conjugated

catalog :

MBS194206

quantity :

0.1 mg

price :

315 USD

clonality :

polyclonal

host :

goat

conjugate :

FITC

reactivity :

human

application :

immunohistochemistry, immunocytochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS194206

products type :

Antibody

products full name :

c-myc Affinity Purified Antibody, FITC Conjugated

products short name :

c-myc FITC

products name syn :

c-myc FITC; c-myc FITC

other names :

c-myc; Myc proto-oncogene protein; myc proto-oncogene protein; OTTHUMP00000158589; OTTHUMP00000227763; proto-oncogene c-Myc; transcription factor p64; class E basic helix-loop-helix protein 39; avian myelocytomatosis viral oncogene homolog; v-myc avian myelocytomatosis viral oncogene homolog; myc-related translation/localization regulatory factor; v-myc myelocytomatosis viral oncogene homolog (avian); Class E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64

other gene names :

MYC; MYC; MRTL; c-Myc; bHLHe39; BHLHE39

uniprot entry name :

MYC_HUMAN

clonality :

Polyclonal

host :

Goat

sequence length :

439

specificity :

c-myc FITC [Goat polyclonal antibody to c-myc FITC Conjugate]

concentration :

1 mg/ml

storage stability :

Store at 4 degree C; stable for one year

tested application :

Immunohistochemistry, Immunocytochemistry

app notes :

Immunohistochemistry/Immunocytochemistry: 0.5-5 ug/ml

other info1 :

Antigen: c-myc (EQKLISEEDL) coupled to KLH

other info2 :

Buffer: Phosphate Buffered Saline, pH 7.2. Stabilizer: 0.2% BSA. Preservatives: 0.1% sodium azide

products categories :

Epitope Tag Antibodies

ncbi gi num :

396512

ncbi acc num :

CAA46984.1

uniprot acc num :

Q6LBK7

ncbi mol weight :

48,804 Da

ncbi pathways :

Acute Myeloid Leukemia Pathway 83117!!Acute Myeloid Leukemia Pathway 529!!Apoptosis Pathway 198797!!Bladder Cancer Pathway 83115!!Bladder Cancer Pathway 527!!C-MYB Transcription Factor Network Pathway 138073!!C-MYC Pathway 169344!!CD40/CD40L Signaling Pathway 138061!!Cell Cycle, Mitotic Pathway 105765!!Cell Cycle Pathway 83054

ncbi summary :

The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq]

uniprot summary :

Function: Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes. Subunit structure: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with KDM5A and KDM5B. Interacts (when phosphorylated at Thr-58 and Ser-62) with FBXW7. Ref.23 Ref.25 Ref.26 Ref.29 Ref.30 Ref.31. Subcellular location: Nucleus nucleoplasm. Nucleus nucleolus Ref.31. Post-translational modification: Phosphorylated by PRKDC. Phosphorylation at Thr-58 and Ser-62 by GSK3 is required for ubiquitination and degradation by the proteasome. Ref.18 Ref.20 Ref.22 Ref.23 Ref.27 Ref.31 Ref.32 Ref.33Ubiquitinated by the SCF(FBXW7) complex when phosphorylated at Thr-58 and Ser-62, leading to its degradation by the proteasome. In the nucleoplasm, ubiquitination is counteracted by USP28, which interacts with isoform 1 of FBXW7 (FBW7alpha), leading to its deubiquitination and preventing degradation. In the nucleolus, however, ubiquitination is not counteracted by USP28, due to the lack of interaction between isoform 4 of FBXW7 (FBW7gamma) and USP28, explaining the selective MYC degradation in the nucleolus. Also polyubiquitinated by the DCX(TRUSS) complex. Ref.18 Ref.20 Ref.22 Ref.23 Ref.27 Ref.31 Ref.32 Ref.33. Involvement in disease: Note=Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors.Note=A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1.Defects in MYC are a cause of Burkitt lymphoma (BL) [. MIM:113970]. A form of undifferentiated malignant lymphoma commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. Note=Chromosomal aberrations involving MYC are usually found in Burkitt lymphoma. Translocations t(8;14), t(8;22) or t(2;8) which juxtapose MYC to one of the heavy or light chain immunoglobulin gene loci. Biotechnological use: POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 are the four Yamanaka factors. When combined, these factors are sufficient to reprogram differenciated cells to an embryonic-like state designated iPS (induced pluripotent stem) cells. iPS cells exhibit the morphology and growth properties of ES cells and express ES cell marker genes. Ref.28. Sequence similarities: Contains 1 basic helix-loop-helix (bHLH) domain.

size :

0.1 mg

price :

315 USD

more info or order :

MyBioSource product webpage