c-myc Affinity Purified Antibody, Agarose Immobilized | MyBioSource MBS194205 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

c-myc Affinity Purified Antibody, Agarose Immobilized

catalog :

MBS194205

quantity :

0.1 mg

price :

335 USD

clonality :

polyclonal

host :

goat

conjugate :

agarose

reactivity :

human

application :

immunoprecipitation

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS194205

products type :

Antibody

products full name :

c-myc Affinity Purified Antibody, Agarose Immobilized

products short name :

Agarose Immobilized Goat anti-c-myc

products name syn :

Agarose Immobilized Goat anti-c-myc

other names :

c-myc; Myc proto-oncogene protein; myc proto-oncogene protein; OTTHUMP00000158589; OTTHUMP00000227763; proto-oncogene c-Myc; transcription factor p64; class E basic helix-loop-helix protein 39; avian myelocytomatosis viral oncogene homolog; v-myc avian myelocytomatosis viral oncogene homolog; myc-related translation/localization regulatory factor; v-myc myelocytomatosis viral oncogene homolog (avian); Class E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64

other gene names :

MYC; MYC; MRTL; c-Myc; bHLHe39; BHLHE39

uniprot entry name :

MYC_HUMAN

host :

Goat

sequence length :

439

specificity :

Agarose Immobilized Goat anti-c-myc

concentration :

100 ug antibody / 200 ul gel

storage stability :

Store at 4 degree C; stable for one year

tested application :

Immunoprecipitation

app notes :

Immunoprecipitation: 15 to 25 ul of gell slurry per 0.1 to 1 mg of protein lysate or extract

other info1 :

Antigen: c-myc (EKLISEEDL) coupled to KLH. Antibody coupled to agarose beads using a cyanogen bromide method.

other info2 :

Buffer: 0.01M Phosphate, pH 7.2, 0.1M NaCl. Stabilizer: None. Preservatives: 0.1% sodium azide

products categories :

Epitope Tag Antibodies

ncbi gi num :

396512

ncbi acc num :

CAA46984.1

uniprot acc num :

Q6LBK7

ncbi mol weight :

48,804 Da

ncbi pathways :

Acute Myeloid Leukemia Pathway (83117); Acute Myeloid Leukemia Pathway (529); Apoptosis Pathway (198797); Bladder Cancer Pathway (83115); Bladder Cancer Pathway (527); C-MYB Transcription Factor Network Pathway (138073); C-MYC Pathway (169344); CD40/CD40L Signaling Pathway (138061); Cell Cycle, Mitotic Pathway (105765); Cell Cycle Pathway (83054)

ncbi summary :

The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq]

uniprot summary :

Myc: a proto-oncogenic transcription factor that plays a role in cell proliferation, apoptosis and in the development of human tumors. Seems to activate the transcription of growth-related genes. Protein type: DNA-binding; Transcription factor; Oncoprotein; Nucleolus. Chromosomal Location of Human Ortholog: 8q24.21. Cellular Component: nucleoplasm; protein complex; nucleolus; cytosol; nucleus. Molecular Function: protein dimerization activity; protein binding; DNA binding; protein complex binding; transcription factor binding; transcription factor activity. Biological Process: oxygen transport; cellular iron ion homeostasis; positive regulation of transcription, DNA-dependent; positive regulation of caspase activity; Wnt receptor signaling pathway through beta-catenin; negative regulation of transcription from RNA polymerase II promoter; chromosome organization and biogenesis; positive regulation of fibroblast proliferation; transforming growth factor beta receptor signaling pathway; positive regulation of cell proliferation; positive regulation of mesenchymal cell proliferation; response to gamma radiation; cell cycle arrest; response to drug; transcription initiation from RNA polymerase II promoter; Notch signaling pathway; transcription, DNA-dependent; regulation of telomere maintenance; MAPKKK cascade; negative regulation of cell division; negative regulation of monocyte differentiation; negative regulation of stress-activated MAPK cascade; chromatin remodeling; negative regulation of fibroblast proliferation; ureteric bud branching; regulation of gene expression; energy reserve metabolic process; gene expression; positive regulation of transcription from RNA polymerase II promoter; response to DNA damage stimulus; positive regulation of epithelial cell proliferation; negative regulation of apoptosis. Disease: Burkitt Lymphoma

size1 :

0.1 mg

price1 :

335 USD

more info or order :

MyBioSource product webpage