antibody

CARD9 Polyclonal Antibody

MBS194186

0.1 mg

370 USD

polyclonal

rabbit

nonconjugated

Antibody

CARD9 Polyclonal Antibody

CARD9

CARD9

caspase recruitment domain-containing protein 9 isoform 2; Caspase recruitment domain family, member 9; caspase recruitment domain-containing protein 9; OTTHUMP00000022569; OTTHUMP00000022571; caspase recruitment domain family, member 9

CARD9; CARD9; CANDF2; hCARD9

Q5SXM5_HUMAN

Polyclonal

Rabbit

536

CARD9 [This rabbit antibody recognizes aa 521-536 of human CARD9, a novel CARD (Caspase Recruitment Domain)-containing protein that interacts with the CARD activation domain of Bcl-10.]. This antibody recognizes human CARD9, a novel CARD (Caspase Recruitment Domain)-containing protein that interacts with the CARD activation domain of Bcl-10. CARD9 associates with Bcl-10 to form a complex within cells. CARD9 induces apoptosis and activates NF- kappa B.

100 ug IgG in PBS, pH 7.4, purified by immunoaffinity chromatography.

This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.

Immunoblot

Immunoblotting: use at 0.5-1 ug/ml. In immunoblots, a band of 59 kD is detected. Positive control: PC-3 cell lysate.

Antigen: Peptide corresponding to aa 521-536 of human CARD9. Thissequence differs from that of rat CARD9by two amino acids.

Stabilizer: None. Preservatives: 0.02% sodium azide. Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.

Apoptosis Antibodies

16554562

NP_434701.1

NM_052814.3

Q5SXM5

62,241 Da

Immune System Pathway (106386); Innate Immunity Signaling Pathway (106387); NOD-like Receptor Signaling Pathway (122191); NOD-like Receptor Signaling Pathway (122131); NOD1/2 Signaling Pathway (366165); Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor (NLR) Signaling Pathways (366164); Tuberculosis Pathway (213780); Tuberculosis Pathway (213743)

The protein encoded by this gene is a member of the CARD protein family, which is defined by the presence of a characteristic caspase-associated recruitment domain (CARD). CARD is a protein interaction domain known to participate in activation or suppression of CARD containing members of the caspase family, and thus plays an important regulatory role in cell apoptosis. This protein was identified by its selective association with the CARD domain of BCL10, a postive regulator of apoptosis and NF-kappaB activation, and is thought to function as a molecular scaffold for the assembly of a BCL10 signaling complex that activates NF-kappaB. Several alternatively spliced transcript variants have been observed, but their full-length nature is not clearly defined. [provided by RefSeq]

CARD9: Activates NF-kappa-B via BCL10. Defects in CARD9 are the cause of familial candidiasis type 2 (CANDF2). Chronic mucocutaneous candidiasis is characterized by impaired clearance of fungal infections and results in colonization and infections of the mucosa or skin, predominantly with Candida albicans. CANDF2 is an autosomal recessive chronic mucocutaneous candidiasis. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Adaptor/scaffold. Chromosomal Location of Human Ortholog: 9q34.3. Cellular Component: cytoplasm. Molecular Function: protein homodimerization activity; CARD domain binding. Biological Process: response to drug; response to fungus; positive regulation of I-kappaB kinase/NF-kappaB cascade; regulation of interleukin-2 biosynthetic process; regulation of interleukin-6 biosynthetic process; positive regulation of interleukin-6 production; positive regulation of JNK cascade; positive regulation of tumor necrosis factor production; positive regulation of stress-activated MAPK cascade; regulation of apoptosis; defense response to Gram-positive bacterium; response to exogenous dsRNA; response to muramyl dipeptide; response to peptidoglycan; innate immune response; defense response to virus; regulation of tumor necrosis factor biosynthetic process. Disease: Candidiasis, Familial, 2

0.1 mg

370 USD