catalog number :
MBS194148
products full name :
Anti-TRICK2 (DR5, TRAIL-R2) Antibody
products short name :
TRICK2 (DR5,TRAIL-R2)
products name syn :
TRICK2 (DR5,TRAIL-R2); TRICK2
specificity :
TRICK2 (DR5,TRAIL-R2) [Human TRICK2 (DR5, TRAIL-R2)]. This antibody recognizes human TRICK2.
form :
100 ug IgG in PBS, pH 7.4, purified by immunoaffinity chromatography.
storage stability :
This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.
tested application :
Immunoblot
app notes :
Immunoblotting: use at 1:500 dilution. A band of approximately 57 kDa is detected. Positive control: whole cell lysate from HL60, HeLa, or Jurkat cells.
other info1 :
Immunogen: Synthetic peptide corresponding to amino acids 409-427 (LGERLAKQKIEDHLLSSGK, isoform 1) of human TRICK2 precursor conjugated to KLH at the N-terminus. The same sequence is found at amino acids 380-398 in isoform 2.
other info2 :
Stabilizer: None. Preservatives: None. Available on request. Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.
products categories :
Apoptosis Antibodies
products description :
Apoptosis is induced by cytokines in the TNF family through their death domain containing receptors. TRICK2 (TRAIL receptor inducer of cell killing 2) is a member of the TNF receptor family and contains the conserved death domain. TRICK2 is expressed at high levels in lymphocytes and spleen cells and in many types of tumor cells. Overexpression of TRICK2 rapidly induces cell death by apoptosis. TRICK2 has been shown to function as a receptor for TRAIL and can inhibit TRAIL-induced killing of lymphocytic cells. Other names for TRICK2 include DR5, Apo2, TRAIL-R2, and KILLER.
products references :
Screaton,GR et al. (1997) Curr Biol 7: 693-696.