catalog number :
MBS194125
products full name :
Anti-p62dok Antibody
products short name :
DOK (CT)
products name syn :
Anti-DOK (CT); DOK (CT)
specificity :
Anti-DOK (CT) [Rabbit antibody to peptide corresponding to aa 425-439 of human p62dok.]. This antibody recognizes human p62dok (62kD).
form :
100 ug IgG in PBS, pH 7.4, purified by immunoaffinity chromatography.
storage stability :
This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.
tested application :
Immunoblot
app notes :
Immunoblotting: use at 1:1,000-1:2,000 dilution. Positive control: Whole cell lysate of Jurkat cells.
other info1 :
Antigen: Peptide corresponding to aa 425-439 of human p62dok.
other info2 :
Stabilizer: None. Preservatives: 0.02% sodium azide. Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.
products categories :
Neuroscience and Signal Transduction Antibodies
products description :
Signals from most growth factors and cytokines are transduced by receptor tyrosine kinases or non-receptor tyrosine kinases. Activated tyrosine kinases phosphorylate their substrates which mediates the cellular response to extracellular stimuli. A long-sought major substrate termed p62dok (downstream of tyrosine kinase) for many tyrosine kinases including c-kit, v-abl, v-Fps, v-Src, v-Fms, and activated EGF, PDGF, IGF, VEGF, and insulin receptors, has been identified in human and mouse. Upon phosphorylation, p62dok forms a complex with the ras GTPase-activating protein (RasGAP). p62dok, along with p56dok, represents a new family of RasGAP-binding proteins.