antibody

Anti-Neurturin Antibody

MBS194122

0.1 mg

370 USD

polyclonal

rabbit

nonconjugated

Antibody

Anti-Neurturin Antibody

Neurturin

Anti-Neurturin; Neurturin

neurturin preproprotein; Neurturin; neurturin; neurturin

NRTN; NRTN; NTN

NRTN_HUMAN

Rabbit

Anti-Neurturin [Rabbit antibody to peptide corresponding to aa 178-193 of human neurturin.]. This antibody recognizes human, neurturin (14 kD).

100 ug IgG in PBS, pH 7.4, purified by immunoaffinity chromatography.

This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.

Immunoblot

Immunoblotting: use at 1:500 dilution.

Antigen: Peptide corresponding to aa 178-193 of human neurturin.

Stabilizer: None. Preservatives: 0.02% sodium azide. Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.

Neuroscience and Signal Transduction Antibodies

Glial cell line-derived neurotrophic factor (GDNF) plays a key role in the conrol of vertebrate neuron survival and differentiation. A novel neurotrophic factor was recently cloned from human and mouse and designated neurturin. (NTN). Physiological responses to NTN require the presence of receptor tyrosine kinase RET and a novel glycosylphosphatidylinositol linked receptor NTNR alpha . The cDNAS encoding NTNR alpha from human, rat, chicken, and mouse have been cloned and referred to as GFR alpha -2, GDNFR beta , Ret ligand 2 (RETL2), and TGF- beta -related neurotrophic factor receptor 2 (TmR2). NTN forms a complex with GFR alpha -2 and the Ret PTK and activates the RET receptor tyrosine kinase pathway. Both NTN and GDNF can activate the MAP kinase and phosphatidylinositol 3-kinase pathways and play a critical role in the development of many neuronal populations.

4758826

NP_004549.1

NM_004558.3

Q99748

22,405 Da

Axon Guidance Pathway (105688); NCAM Signaling For Neurite Out-growth Pathway (105689); NCAM1 Interactions Pathway (105697)

Neurturin is a member of the TGF-beta subfamily, TRN. This gene signals through RET and a GPI-linked coreceptor, and promotes survival of neuronal populations. A neurturin mutation has been described in a family with Hirschsprung Disease. [provided by RefSeq]

NRTN: Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells. Genetic variations in NRTN may contribute to Hirschsprung disease, in association with mutations of RET gene, and possibly mutations in other loci. Hirschsprung disease is a disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction. Belongs to the TGF-beta family. GDNF subfamily. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 19p13.3. Cellular Component: axon; extracellular region. Molecular Function: growth factor activity; receptor binding. Biological Process: nervous system development; axon guidance; MAPKKK cascade; nerve development; neural crest cell migration; neurite development; transmembrane receptor protein tyrosine kinase signaling pathway. Disease: Hirschsprung Disease, Susceptibility To, 1

0.1 mg

370 USD