antibody

Anti-IRAK2 Antibody

MBS194111

0.1 mg

370 USD

polyclonal

rabbit

nonconjugated

Antibody

Anti-IRAK2 Antibody

IRAK2

Anti-IRAK2; IRAK2 (CT)

Rabbit

Anti-IRAK2 [Rabbit antibody to peptide corresponding to aa 546-564 of human IRAK2.]. This antibody recognizes full-length human IRAK2 (65 kD).

100 ug IgG in PBS, pH 7.4, purified by immunoaffinity chromatography.

This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.

Immunoblot

Immunoblotting: use at 1:500-1:1,000 dilution. Positive control: Whole cell lysate from HeLa cells or K562 cells. No crossreactivity with IRAK.

Antigen: Peptide corresponding to aa 546- 564 of human IRAK2.

Stabilizer: None. Preservatives: 0.02% sodium azide. Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.

Neuroscience and Signal Transduction Antibodies

The pro-inflammatory cytokine IL-1 induces cellular responses through two subunits of its receptor, IL-1 receptor 1 (IL-1R1) and IL- 1 receptor accessory protein (IL-1RacP). IL-1 receptor-associated kinase (IRAK) mediates activation of NF- kappa B, a key transcription factor that mediates inflammatory and immune respones. A novel member of the IRAK/Pelle family was recently identified and designated IRAK2. Both IRAK and IRAK2 associate with the subunits of the IL-1R complex after IL-1 binding and lead to NF- kappa B activation. IRAKs also associate with Toll-like receptor (TLR) and the dominant negative mutants of IRAKs inhibit LPS-induced NF- kappa B activation. Members of the IRAK/Pelle family play a central role in IL-1R and TLRmediated inflammatory responses. IRAK2 is expressed in a variety of human tissues.

0.1 mg

370 USD