antibody

Anti-IKK alpha Antibody

MBS194101

0.1 mg

370 USD

polyclonal

rabbit

nonconjugated

Antibody

Anti-IKK alpha Antibody

IKK alpha (C1)

Anti-IKK alpha (C1); IKKalpha

Rabbit

Anti-IKK alpha (C1) [Rabbit antibody to peptide corresponding to aa 716-734 of human IKKa.]. This antibody recognizes human IKK alpha (85 kD). No cross-reactivity with IKK beta or IKK gamma .

100 ug IgG in PBS, pH 7.4, purified by immunoaffinity chromatography.

This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.

Immunoblot

Immunoblotting: use at 1:1,000-1:2,000 dilution. Positive control: Whole cell lysate from HeLa or Jurkat cells.

Antigen: Peptide corresponding to aa 716-734 of human IKK alpha which differs from the corresponding murine sequence by four amino acids.

Stabilizer: None. Preservatives: 0.02% sodium azide. Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.

Neuroscience and Signal Transduction Antibodies

Nuclear factor kappa B (NF- kappa B) is a ubiquitous transcription factor and key mediator of gene expression during immune and inflammatory responses. NF- kappa B activates numerous genes in response to extracellular stimuli, such as IL-1, TNF alpha , and LPS. NF- kappa B is associated with I kappa B in cytoplasm, which inhibits NF- kappa B activity. I kappa B kinase (IKK), which phosphorylates I kappa B and mediates I kappa B degradation and NF- kappa B activation, was recently identified. IKK is a serine protein kinase, and the IKK complex contains alpha and beta subunits (IKK alpha and IKK beta ). IKK alpha and IKK beta interact with each other, and both are essential for NF-B activation. IKK alpha specifically phosphorylates I kappa B- alpha and is expressed in a variety of human tissues.

0.1 mg

370 USD