catalog number :
MBS194092
products full name :
Anti-GFR alpha -2 Antibody
products short name :
GFR-2 (IN)
products name syn :
Anti-GFR-2 (IN); GFRa-2
specificity :
Anti-GFR-2 (IN) [Rabbit antibody to peptide corresponding to aa 377-391 of human GFRa-2. Recognizes human, mouse, and rat GFRa-2.]. This antibody recognizes human, mouse, and rat GFR alpha -2 (52 kD).
form :
100 ug IgG in PBS, pH 7.4, purified by immunoaffinity chroma-tography.
storage stability :
This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.
tested application :
Immunoblot
app notes :
Immunoblotting: use at 1:1,000-1:2,000 dilution. Positive control: Whole cell lysate of HeLa cells.
other info1 :
Antigen: Peptide corresponding to aa 377- 391 of human GFR alpha -2. This peptide sequence is identical to those of mouse and rat.
other info2 :
Stabilizer: None. Preservatives: 0.02% sodium azide. Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.
products categories :
Neuroscience and Signal Transduction Antibodies
products description :
Members of the glial cell line-derived neurotrophic factor (GDNF) family, including GDNF and neurturin (NTN), play key roles in the control of vertebrate neuronal survivial and differentiation. Physiological responses to NTN require the presence of a novel glycosylphosphatidylinositol linked protein, NTNR alpha , which is a cell surface receptor for NTN. The cDNAs encoding NTNR alpha from human, rat, chicken, and mouse have been cloned. NTNR alpha has also been referred to as GFR alpha -2, GDNFR beta , Ret ligand 2 (RETL2), and TGF- beta -related neurotrophic factor receptor 2 (TmR2). GFR alpha -2 binds NTN and mediates activation of RET receptor tyrosine kinase by both NTN and GDNF. Thus, NTN, GFR alpha -2, and the Ret PTK form a complex to transmit the NTN signal and to mediate NTN function.