catalog number :
MBS194091
products full name :
Anti-GFR alpha -1 Antibody
products short name :
GFR-1 (IN)
products name syn :
Anti-GFR-1 (IN); GFRa-1
specificity :
Anti-GFR-1 (IN) [Rabbit antibody to peptide corresponding to aa 369-382 of human GFRa-1. Recognizes human, mouse, and rat GFRa-1.]. This antibody recognizes human, mouse, and rat GFR alpha -1 (approx. 50 kD).
form :
100 ug IgG in PBS, pH 7.4, purified by immunoaffinity chromatography.
storage stability :
This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.
tested application :
Immunoblot
app notes :
Immunoblotting: use at 1:500 dilution.
other info1 :
Antigen: Peptide corresponding to aa 369- 382 of human GFR alpha -1. This peptide sequence is identical to those of mouse and rat.
other info2 :
Stabilizer: None. Preservatives: 0.02% sodium azide. Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.
products categories :
Neuroscience and Signal Transduction Antibodies
products description :
Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of the kidney and the enteric nervous system. Physiological responses to GDNF require the presence of a novel glycosylphosphatidylinositol linked protein, GDNFR alpha , a cell surface receptor for GDNF. The cDNAs encoding GDNFR alpha from human, rat, chicken, and mouse have been cloned. GDNFR alpha has also been referred to as GFR alpha -1, Ret ligand 1 (RETL1) and TGF- beta -related neurotrophic factor receptor 1 (TmR1). GFR alpha -1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK). Thus, GDNF, GFR alpha , and the Ret PTK form a complex to transmit the GDNF signal and to mediate GDNF function. GFR alpha -1 has been identified in brain, liver, kidney, and spleen.