antibody

Anti-Eotaxin Antibody

MBS194080

0.1 mg

370 USD

polyclonal

rabbit

nonconjugated

Antibody

Anti-Eotaxin Antibody

Eotaxin (CT)

Eotaxin (CT); Eotaxin

eotaxin; Eotaxin; eotaxin; eotaxin-1; OTTHUMP00000163793; C-C motif chemokine 11; small-inducible cytokine A11; eosinophil chemotactic protein; small inducible cytokine subfamily A (Cys-Cys), member 11 (eotaxin); chemokine (C-C motif) ligand 11; C-C motif chemokine 11; Eosinophil chemotactic protein; Small-inducible cytokine A11

CCL11; CCL11; SCYA11; MGC22554; SCYA11

CCL11_HUMAN

Rabbit

Eotaxin (CT) [Rabbit antibody to peptide corresponding to aa 83-97 of human eotaxin, an eosinophil chemoattractant.]. This antibody recognizes the monomeric (9 kD) and dimeric (18 kD) forms of human eotaxin

100 ug IgG in 200 ulPBS, pH 7.4, purified by immunoaffinity chromatography.

This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.

Immunoblot

Immunoblotting: use at 1:500-1:1,000 dilution. Positive control: Native and recombinant protein.

Antigen: Peptide corresponding to aa 83-97 of human eotaxin.

Stabilizer: None. Preservatives: 0.02% sodium azide. Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.

Infectious Disease Antibodies

Chemokines play a key role in inflammation. The CC chemokine eotaxin is a potent and specific eosinophil chemoattractant that is expressed by a variety of cell types in certain inflammatory conditions. Some G-protein coupled chemokine receptors are also utilized as virus coreceptors for fusion and infection of cells. The eotaxin receptor CCR3 is required for HIV-1 entry into target cells such as microglia, and eotaxin inhibits infection by HIV-1.

2462478

CAB07027.1

P51671

10,732 Da

Asthma Pathway (83120); Asthma Pathway (532); CXCR3-mediated Signaling Events Pathway (138011); Chemokine Receptors Bind Chemokines Pathway (106359); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); GPCR Ligand Binding Pathway (161020)

This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil specific chemokine assumed to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. [provided by RefSeq]

CCL11: In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3. Belongs to the intercrine beta (chemokine CC) family. Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 17q12. Cellular Component: extracellular space; extracellular region. Molecular Function: protein binding; chemokine activity. Biological Process: chronic inflammatory response; mast cell chemotaxis; response to virus; actin filament organization; cytoskeleton organization and biogenesis; signal transduction; chemotaxis; protein amino acid phosphorylation; cellular calcium ion homeostasis; regulation of cell shape; positive regulation of angiogenesis; response to radiation; positive regulation of actin filament polymerization; eosinophil chemotaxis; immune response; positive regulation of endothelial cell proliferation; cell adhesion; inflammatory response; positive regulation of cell migration. Disease: Asthma, Susceptibility To; Human Immunodeficiency Virus Type 1, Susceptibility To

0.1 mg

370 USD