catalog number :
MBS194061
products full name :
Anti-DcR3 (NT) Antibody
products short name :
DcR3 (NT)
products name syn :
Anti-DcR3 (NT); DcR3 (NT)
other names :
decoy receptor 3 variant 2
specificity :
Anti-DcR3 (NT) [Rabbit antibody to peptide corresponding to aa 31-46 of human DcR3 precursor. Recognizes human, mouse, and rat DcR3.]. This antibody recognizes human, mouse, and rat DcR3 (33 kD).
form :
100 ug IgG in PBS, pH 7.4, purified by immunoaffinity chromatography.
storage stability :
This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.
tested application :
Immunoblot
app notes :
Immunoblotting: use at 1:500-1:1,000 dilution. Positive control: Human heart tissue lysate.
other info1 :
Antigen: Peptide corresponding to aa 31- 46 of human DcR3 precursor.
other info2 :
Stabilizer: None. Preservatives: 0.02% sodium azide. Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.
products categories :
Apoptosis Antibodies
products description :
Apoptosis is induced by certain cytokines including TNF and Fas ligand through their death domain-containing receptors. Several novel members in the TNF receptor family, including DR3, DR4, DR5 and DR6, function as cell death receptors. Two decoy receptors, DcR1 and DcR2, compete with DR4 and DR5 for binding of their ligand, TRAIL. Another decoy receptor, DcR3/TR6 was discovered recently. Unlike DcR1 and DcR2, DcR3 is a soluble rather than a membrane-associated molecule. DcR3 binds to FasL and LIGHT and inhibits FasLand LIGHT-induced apoptosis. DcR3 transcript is expressed in some lung and colon carcinomas and in some normal tissues.
ncbi pathways :
Focal Adhesion Pathway 83067!!Focal Adhesion Pathway 478!!MAPK Signaling Pathway 83048!!MAPK Signaling Pathway 456!!Salmonella Infection Pathway 375172!!Salmonella Infection Pathway 375149