catalog number :
MBS194060
products full name :
Anti-DcR2 Antibody
products short name :
DcR2
products name syn :
Anti-DcR2; DcR2
other names :
Dicer-2; CG6493 gene product from transcript CG6493-RA; Dicer-2; CG6493-PA; Dcr-2-PA; Dicer2; dicer 2; Dicer-2
other gene names :
Dcr-2; cg6493; CG6493; dcr-2; DCR-2; dcr2; Dcr2; DCR2; dicer; Dicer; DICER; dicer2; DmelCG6493
specificity :
Anti-DcR2 [Rabbit antibody to peptide corresponding to aa 249-263 of human DcR2 receptor precursor.]. This antibody recognizes full-length DcR2(34 kD).
form :
100 ug IgG in PBS, pH 7.4, purifiedby immunoaffinity chromatography.
storage stability :
This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.
tested application :
Immunoblot
app notes :
Immunoblotting: use at 1:1,000-1:2,000 dilution. Positive control: Whole cell lysate from HeLa cells.
other info1 :
Antigen: Peptide corresponding to aa 249-263 of human DcR2 precursor.
other info2 :
Stabilizer: None. Preservatives: 0.02% sodium azide. Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.
products categories :
Apoptosis Antibodies
products description :
Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domaincontaining receptors. TRAIL/Apo2L is a new member of the TNF familyand induces apoptosis in a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL, and DcR1/TRID is a "decoy receptor". Another member of the TRAIL receptor family was more recently identified and designated DcR2, TRAIL-R4, or TRUNDD. DcR2 has an extracellular TRAIL-binding domain but lacks an intracellular death domain and does not induce apoptosis. Like DR4 and DR5, DcR2 transcript is widely expressed in normal human tissues. Overexpression of DcR2 attenuates TRAIL-induced apoptosis.
ncbi acc num :
NP_523778.2
ncbi gb acc num :
NM_079054.3
ncbi pathways :
MicroRNA (miRNA) Biogenesis Pathway 365620!!Regulatory RNA Pathways 365619