catalog number :
MBS194059
products full name :
Anti-DcR1 (ED2) Antibody
products short name :
DcR1 (ED2)
products name syn :
Anti-DcR1 (ED2); DcR1 (ED2)
other names :
Dicer-1; CG4792 gene product from transcript CG4792-RA; Dicer-1; CG4792-PA; Dcr-1-PA; Dicer1; dicer; Dicer-1
other gene names :
Dcr-1; cg4792; CG4792; Dcr; dcr 1; dcr-1; dcr1; Dcr1; DCR1; dicer; Dicer; DICER; dicer-1; dicer1; Dicer1; DmelCG4792
specificity :
Anti-DcR1 (ED2) [Rabbit antibody to peptide corresponding to aa 111-123 in the extracellular domain of human DcR1 precursor.]. This antibody recognizes human, mouse, and rat DcR1 (65 kD).
form :
100 ug IgG in PBS, pH 7.4, purified by immunoaffinity chromatography.
storage stability :
This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.
tested application :
Immunoblot
app notes :
Immunoblotting: use at 1:500-1:1,000 dilution. Positive control: Whole cell lysate from HeLa cells.
other info1 :
Antigen: Peptide corresponding to aa 111-123 at the extracellular domain (ED) of human DcR1 precursor.
other info2 :
Stabilizer: None. Preservatives: 0.02% sodium azide. Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.
products categories :
Apoptosis Antibodies
products description :
Apoptosis is induced by certain cytokines including TNF and Fas ligand through their death domain-containing receptors. TRAIL/Apo2L is a new member of the TNF family that induces apoptosis in a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL. Two decoy receptors for TRAIL have been designated DcR1/TRID/TRAIL-R3/LIT and DcR2/TRAIL-R4/TRUNDD. DcR1 has an extracellular TRAIL-binding domain but lacks an intracellular signaling domain. It is a glycophospholipid-anchored cell surface protein. DcR1 transcripts are expessed in many normal human tissues but not in most cancer cell lines. Overexpression of DcR1 does not induce apoptosis but attenuates TRAILinduced apoptosis.
ncbi acc num :
NP_524453.1
ncbi gb acc num :
NM_079729.2
ncbi pathways :
MicroRNA (miRNA) Biogenesis Pathway (365620); Regulatory RNA Pathways (365619); MRNA Processing Pathway (198267)