antibody

Anti-DAP Kinase 2 Antibody

MBS194056

0.1 mg

370 USD

polyclonal

rabbit

nonconjugated

Antibody

Anti-DAP Kinase 2 Antibody

DAPK2

Anti-DAPK2; DAP Kinase 2

death-associated protein kinase 2; Death-associated protein kinase 2; death-associated protein kinase 2; DAP kinase 2; OTTHUMP00000163874; DAP-kinase-related protein 1 beta isoform; death-associated protein kinase 2; DAP-kinase-related protein 1

DAPK2; DAPK2; DRP1; DRP-1; MGC119312

DAPK2_HUMAN

Rabbit

Anti-DAPK2 [Rabbit antibody to peptide corresponding to aa 356-370 of human DAP Kinase 2. Recognizes human, mouse and rat DAP Kinase 2.]. This antibody recognizes human, mouse, and rat DAPK2 (approx. 42 kD). No crossreactivity with DAPK.

100 ug IgG in 200 ul PBS, pH 7.4, purified by immunoaffinity chromatography.

This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.

Immunoblot

Immunoblotting: use at 1:500-1:1,000 dilution. Positive control: Whole cell lysate from A431cells.

Antigen: Peptide corresponding to aa 356- 370 of human DAPK2. This sequence is identical to that of mouse.

Stabilizer: None. Preservatives: 0.02% sodium azide. Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.

Apoptosis Antibodies

Apoptosis is mediated by death domaincontaining adapter molecules and the caspase family of proteases. Certain serine/threonine protein kinases, such as RIP and DAP kinase, are mediators of apoptosis. DAP kinase (DAPK) is a proapoptotic, calcium-regulated serine/threonine kinase containing a death domain. Expression of DAPK induces cell death and suppresses oncogenic transformation. DAPK mediates IFN gamma -induced apoptosis. A DAPK-related protein was recently described and designated DAPK2, or DRP-1. Expression of DAPK2 induces apoptosis. The messenger RNA for DAPK2 is expressed in multiple human tissues.

14670383

NP_055141.2

NM_014326.3

Q9UIK4

42,898 Da

Apoptosis Pathway (105648); Bladder Cancer Pathway (83115); Bladder Cancer Pathway (527); Pathways In Cancer (83105); Regulation Of Apoptosis Pathway (105685); Role Of DCC In Regulating Apoptosis Pathway (161011)

This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis. It uses multiple polyadenylation sites. [provided by RefSeq]

DAPK2: an ubiquitously expressed protein kinase of the DAPK family. Activated by Ca(2+)/calmodulin. Contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain. Overexpression induces apoptosis. Expressed at high levels in heart, lung and skeletal muscle. Protein type: EC 2.7.11.1; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; CAMK group; DAPK family. Chromosomal Location of Human Ortholog: 15q22.31. Cellular Component: cytoplasm; cytoplasmic vesicle. Molecular Function: calmodulin binding; protein serine/threonine kinase activity; identical protein binding; protein binding; calmodulin-dependent protein kinase activity; ATP binding. Biological Process: regulation of apoptosis; apoptosis; protein amino acid autophosphorylation; regulation of autophagy; protein amino acid phosphorylation; anoikis

0.1 mg

370 USD