antibody

Anti-CXCR4 (NT) Antibody

MBS194055

0.1 mg

370 USD

polyclonal

rabbit

nonconjugated

western blot, immunocytochemistry, immunoprecipitation

Antibody

Anti-CXCR4 (NT) Antibody

HIV Co-Receptor CXCR4 (NT)

HIV Co-Receptor CXCR4 (NT); HIV Co-Receptor CXCR4 (NT)

Polyclonal

Rabbit

HIV Co-Receptor CXCR4 (NT) [Polyclonal (rabbit) antibody to the CXCR4 coreceptor for T-cell tropic strains of HIV-1.]. This antibody recognizes full-length human CXCR4 (40 kD).

100 ug IgG in PBS, pH 7.4, purified by immunoaffinity chromatography.

This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.

Immunoblot, Immunocytochemistry, Immunoprecipitation

Immunoblotting: use at 1:1,000-1:2,000 dilution. Immunoprecipitation: use at 1:1,000-1:2,000 dilution. Immunocytochemistry: use at 1:1,000-1:1,2000 dilution. Positive control: Whole cell lysate from HeLa cells.

Antigen: Peptide corresponding to the Nterminus of human CXCR4

Stabilizer: None. Preservatives: 0.02% sodium azide. Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.

Infectious Disease Antibodies

Human immunodeficiency virus (HIV) and related viruses require coreceptors in addition to CD4 to infect target cells. Some G protein-coupled receptors in the chemokine receptor family, including CCR5, CXCR4, CCR3, CCR2b, and CCR8 have been identified as HIV coreceptors. CXCR4 (also called Fusin, LESTR, HUMSTR) is a principal coreceptor for T-cell tropic strains of HIV-1. CXCR4 is also required for the infection by dual-tropic strains of HIV-1 and mediates CD4-independent infection by HIV-2. CXCR4 associates with the surface CD4-gp120 complex before HIV enters target cells. The amino-terminal domain and the second extracellular loop of CXCR4 serve as HIV binding sites. CXCR4 messenger RNA levels correlate with HIV-1 permissiveness in diverse human cell types. Antibodies to CXCR4 may block HIV-1 and HIV-2 fusion and infection of human target cells.

0.1 mg

370 USD