Anti-CX3CR1 (NT) Antibody | MyBioSource MBS194053 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-CX3CR1 (NT) Antibody

catalog :

MBS194053

quantity :

0.1 mg

price :

370 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS194053

products type :

Antibody

products full name :

Anti-CX3CR1 (NT) Antibody

products short name :

CX3CR1 (NT)

products name syn :

Anti-CX3CR1 (NT); HIV Co-Receptor CX3CR1 (NT)

other names :

CX3C chemokine receptor 1; CX3C chemokine receptor 1; CX3C chemokine receptor 1; CMK-BRL1; CMK-BRL-1; C-X3-C CKR-1; OTTHUMP00000209587; OTTHUMP00000209588; OTTHUMP00000209589; fractalkine receptor; G protein-coupled receptor 13; G-protein coupled receptor 13; chemokine (C-X3-C) receptor 1; beta chemokine receptor-like 1; chemokine (C-C) receptor-like 1; chemokine (C-X3-C motif) receptor 1; Beta chemokine receptor-like 1; CMK-BRL-1; CMK-BRL1; Fractalkine receptor; G-protein coupled receptor 13; V28

other gene names :

CX3CR1; CX3CR1; V28; CCRL1; GPR13; CMKDR1; GPRV28; CMKBRL1; CMKBRL1; GPR13

uniprot entry name :

CX3C1_HUMAN

host :

Rabbit

specificity :

Anti-CX3CR1 (NT) [Rabbit antibody to peptide corresponding to aa 2-21 of human CXCR1. The sequence differs from mouse and rat CX3CR1 by four amino acids.]. This antibody recognizes human, mouse and rat CX3CR1 (50 kD).

form :

100 ug IgG in PBS, pH 7.4, purified by immunoaffinity chromatography.

storage stability :

This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.

tested application :

Immunoblot

app notes :

Immunoblotting: use at 1:500-1:2,000 dilution. Positive control: Tissue lysate from human spleen.

other info1 :

Antigen: Peptide corresponding to aa 2-21 of human CX3CR1. The sequence differs from mouse and rat CX3CR1 by four amino acids.

other info2 :

Stabilizer: None. Preservatives: 0.02% sodium azide. Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.

products categories :

Infectious Disease Antibodies

products description :

CX3CR1 is one of the chemokine receptors that are required as coreceptors for HIV infection. The genes encoding human, murine, and rat CX3CR1 have been cloned and designated V28 and CMKBRL1, CX3CR1, and RBS11, respectively. CX3CR1 was recently identified as the receptor for the chemokine fractalkine. CX3CR1 mediates leukocyte migration and adhesion and is expressed in a variety of human tissues and cell lines.

ncbi gi num :

1351394

ncbi acc num :

P49238.1

uniprot acc num :

P49238

ncbi mol weight :

40,396 Da

ncbi pathways :

Chemokine Receptors Bind Chemokines Pathway (106359); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); GPCR Ligand Binding Pathway (161020); GPCRs, Class A Rhodopsin-like Pathway (198886); Peptide GPCRs Pathway (198897); Peptide Ligand-binding Receptors Pathway (106358)

ncbi summary :

Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq]

uniprot summary :

CX3CR1: Receptor for the CX3C chemokine fractalkine and mediates both its adhesive and migratory functions. Acts as coreceptor with CD4 for HIV-1 virus envelope protein (in vitro). Isoform 2 and isoform 3 seem to be more potent HIV-1 coreceptors than isoform 1. Defects in CX3CR1 are a cause of susceptibility to age- related macular degeneration type 12 (ARMD12). ARMD12 is a form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, multi-pass; Receptor, cytokine; Cell adhesion; Motility/polarity/chemotaxis; Membrane protein, integral; GPCR, family 1; Receptor, GPCR. Chromosomal Location of Human Ortholog: 3p21.3. Cellular Component: neuron projection; integral to plasma membrane; perinuclear region of cytoplasm; plasma membrane. Molecular Function: protein binding; chemokine receptor activity; C-X3-C chemokine receptor activity. Biological Process: G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; positive regulation of angiogenesis; cerebral cortex cell migration; viral reproduction; response to wounding; cellular defense response; cell adhesion; chemotaxis; negative regulation of cell migration; macrophage chemotaxis; microglial cell activation during immune response. Disease: Macular Degeneration, Age-related, 12; Coronary Heart Disease, Susceptibility To, 1; Human Immunodeficiency Virus Type 1, Susceptibility To

size1 :

0.1 mg

price1 :

370 USD

more info or order :

MyBioSource product webpage