Anti-CCR8 Antibody | MyBioSource MBS194048 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-CCR8 Antibody

catalog :

MBS194048

quantity :

0.1 mg

price :

370 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS194048

products type :

Antibody

products full name :

Anti-CCR8 Antibody

products short name :

CCR8 (EL)

products name syn :

Anti-CCR8 (EL); HIV Co-Receptor CCR8 (EL)

other names :

C-C chemokine receptor type 8; C-C chemokine receptor type 8; C-C chemokine receptor type 8; OTTHUMP00000161964; CC chemokine receptor 8; chemokine receptor-like 1; chemokine (C-C) receptor 8; CC chemokine receptor CHEMR1; CC-chemokine receptor chemr1; chemokine (C-C) receptor-like 2; chemokine (C-C motif) receptor 8; CC chemokine receptor CHEMR1; CMKBRL2; Chemokine receptor-like 1; CKR-L1; GPR-CY6; GPRCY6; TER1

other gene names :

CCR8; CCR8; CY6; TER1; CCR-8; CKRL1; CDw198; CMKBR8; GPRCY6; CMKBRL2; CC-CKR-8; MGC129966; MGC129973; CKRL1; CMKBR8; CMKBRL2

uniprot entry name :

CCR8_HUMAN

host :

Rabbit

specificity :

Anti-CCR8 (EL) [Rabbit antibody to peptide corresponding to aa 183-201 of human CCR8 which is located in the second extracellular loop.]. This antibody recognizes human CCR8 (50 kD).

form :

100 ug IgG in PBS, pH 7.4, purified by immunoaffinity chromatography.

storage stability :

This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.

tested application :

Immunoblot

app notes :

Immunoblotting: use at 1:500-1:1,000 dilution. Positive control: Tissue lysate from human spleen.

other info1 :

Antigen: Peptide corresponding to aa 183-201 of human CCR8 which is located in the second extracellular loop.

other info2 :

Stabilizer: None. Preservatives: 0.02% sodium azide. Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.

products categories :

Infectious Disease Antibodies

products description :

CCR8 is one of the chemokine receptors that are required as coreceptors for HIV infection. The genes encoding human and murine CCR8 have been cloned and designated TER1, CKR-L1, and ChemR1. The encoded seven transmembrane protein was identified as the receptor for human CC chemokine I-309 and renamed CCR8. Recently, CCR8 was found to serve as a coreceptor for diverse T-cell tropic, dual-tropic and macrophagetropic HIV-1 strains. CCR8 mediates CC chemokine I-309 induced monocyte chemoattraction and HIV-1 envelope fusion and virus infection. CCR8 is expressed in spleen, thymus, and T lymphoblastic cell lines.

ncbi gi num :

4885121

ncbi acc num :

NP_005192.1

ncbi gb acc num :

NM_005201.3

uniprot acc num :

P51685

ncbi mol weight :

40,844 Da

ncbi pathways :

Chemokine Receptors Bind Chemokines Pathway (106359); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); G Alpha (i) Signalling Events Pathway (119550); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); GPCRs, Class A Rhodopsin-like Pathway (198886)

ncbi summary :

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region. [provided by RefSeq]

uniprot summary :

CCR8: Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection. Belongs to the G-protein coupled receptor 1 family. Protein type: GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR; Motility/polarity/chemotaxis; Membrane protein, integral. Chromosomal Location of Human Ortholog: 3p22. Cellular Component: integral to plasma membrane; plasma membrane. Molecular Function: C-C chemokine receptor activity; chemokine receptor activity; coreceptor activity. Biological Process: G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; immune response; cell adhesion; chemotaxis

size1 :

0.1 mg

price1 :

370 USD

more info or order :

MyBioSource product webpage