Anti-Bnip3L (IN) Antibody | MyBioSource MBS194037 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-Bnip3L (IN) Antibody

catalog :

MBS194037

quantity :

0.1 mg

price :

360 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS194037

products type :

Antibody

products full name :

Anti-Bnip3L (IN) Antibody

products short name :

Bnip3L (IN)

products name syn :

Anti-Bnip3L (IN); Bnip3L (IN)

other names :

BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like; NIP3L; OTTHUMP00000125280; OTTHUMP00000225446; OTTHUMP00000225447; OTTHUMP00000225448; OTTHUMP00000225568; NIP3-like protein X; adenovirus E1B19k-binding protein B5; BCL2/adenovirus E1B 19-kd protein-interacting protein 3a; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A; BCL2/adenovirus E1B 19kDa interacting protein 3-like; Adenovirus E1B19K-binding protein B5; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A; NIP3-like protein X

other gene names :

BNIP3L; BNIP3L; NIX; BNIP3a; BNIP3A; BNIP3H; NIX

uniprot entry name :

BNI3L_HUMAN

host :

Rabbit

specificity :

Anti-Bnip3L (IN) [Rabbit antibody to peptide corresponding to aa 77-92 of human Bnip3L. Recognizes human and mouse Bnip3L.]. This antibody recognizes monomeric human and mouse Bnip3L. A band of 40 kD is detected in immunoblots.

form :

100 ug IgG in PBS, pH 7.4, purified by immunoaffinity chromatography.

storage stability :

This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.

tested application :

Immunoblot

app notes :

Immunoblotting: use at 0.5-1.0 ug/ml. Positive control: Whole cell lysate of human K562 cells.

other info1 :

Antigen: Peptide corresponding to aa 77- 92 of human Bnip3L. This amino acid sequence is identical to that of mouse.

other info2 :

Stabilizer: None. Preservatives: 0.02% sodium azide. Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.

products categories :

Apoptosis Antibodies

products description :

Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain, and BH3 domain-containing pro-apoptotic proteins (such as Bad, Bax, Bid, Bik, and Hrk) form a growing subclass of the Bcl-2 family. A novel BH3 domain-containing protein was recently identified and designated Bnip3L, Bnip3 alpha , or Nix. Bnip3L is a homolog of the E1B 19K/Bcl-2 binding and pro-apoptotic protein Bnip3. Overexpression of Bnip3L induces apoptosis. Bnip3L interacts with and overcomes suppression by Bcl-2 and BclxL. Bnip3L is localized in mito-chondria. The messenger RNA of Bnip3L is ubiquitously expressed in human tissues. Bnip3L and Bnip3 form a new subfamily of the pro-apoptotic-mitochondrial proteins.

ncbi gi num :

4757860

ncbi acc num :

NP_004322.1

ncbi gb acc num :

NM_004331.2

uniprot acc num :

O60238

ncbi mol weight :

23,930 Da

ncbi pathways :

Apoptosis Pathway 198797!!Direct P53 Effectors Pathway 137939

ncbi summary :

This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. This protein counteracts the apoptotic inducer BNIP3 and may play a role in tumor suppression. [provided by RefSeq]

uniprot summary :

Function: Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. May function as a tumor suppressor. Ref.4 Ref.12. Subunit structure: Self-associates. Interacts with BNIP3 and STEAP3. Interacts with SPATA18/MIEAP. Interacts with human adenovirus-2 E1B 19 kDa protein. Ref.4 Ref.10 Ref.12. Subcellular location: Nucleus envelope. Endoplasmic reticulum. Mitochondrion outer membrane. Membrane; Single-pass membrane protein. Potential Ref.4 Ref.12. Post-translational modification: Undergoes progressive proteolysis to an 11 kDa C-terminal fragment, which is blocked by the proteasome inhibitor lactacystin. Sequence similarities: Belongs to the NIP3 family. Sequence caution: The sequence CAI46217.1 differs from that shown. Reason: Erroneous termination at position 122. Translated as Glu.

size :

0.1 mg

price :

360 USD

more info or order :

MyBioSource product webpage