Anti-BAFF (CT) Antibody | MyBioSource MBS194033 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-BAFF (CT) Antibody

catalog :

MBS194033

quantity :

0.1 mg

price :

370 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS194033

products type :

Antibody

products full name :

Anti-BAFF (CT) Antibody

products short name :

BAFF (CT)

products name syn :

Anti-BAFF (CT); BAFF (CT)

other names :

B-cell activating factor; Tumor necrosis factor ligand superfamily member 13B; tumor necrosis factor ligand superfamily member 13B; delta BAFF; Delta4 BAFF; OTTHUMP00000018691; B-lymphocyte stimulator; B-cell-activating factor; ApoL related ligand TALL-1; TNF homolog that activates apoptosis; dendritic cell-derived TNF-like molecule; tumor necrosis factor-like protein ZTNF4; TNF and ApoL-related leukocyte expressed ligand 1; tumor necrosis factor (ligand) superfamily, member 20; tumor necrosis factor (ligand) superfamily, member 13b; B lymphocyte stimulator; BLyS; B-cell-activating factor; BAFF; Dendritic cell-derived TNF-like molecule; TNF- and APOL-related leukocyte expressed ligand 1

other gene names :

TNFSF13B; TNFSF13B; DTL; BAFF; BLYS; CD257; TALL1; THANK; ZTNF4; TALL-1; TNFSF20; BAFF; BLYS; TALL1; TNFSF20; ZTNF4

uniprot entry name :

TN13B_HUMAN

host :

Rabbit

specificity :

Anti-BAFF (CT) [Rabbit antibody to peptide corresponding to aa 254-269 of human BAFF. Recognizes human, mouse, and rat BAFF.]. This antibody recognizes human, mouse, and rat BAFF (approx. 38 kD).

form :

100 ug IgG in 200 ul PBS, pH 7.4, purified by immunoaffinity chromatography.

storage stability :

This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.

tested application :

Immunoblot

app notes :

Immunoblotting: use at 1:500-1:2,000 dilution. Positive control: Whole cell lysate from HL60 cells.

other info1 :

Antigen: Peptide corresponding to aa 254- 269 at the C-terminus of human BAFF.

other info2 :

Stabilizer: None. Preservatives: 0.02% sodium azide. Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.

products categories :

Apoptosis Antibodies

products description :

Members of the TNF superfamily regulate immune responses and induce apoptosis. A novel member of the TNF superfamily was recently identified and designated BAFF (B Cell Activating Factor of the TNF Family) or BlyS (B Lymphocyte Stimulator), TALL-1 (TNF- and ApoL-Related Leukocyte-Expressed Ligand), and THANK (TNF Homologue that Activates Apoptosis, NF- kappa B and c-jun N-terminal Kinase). BAFF is designated a B cell stimulator since it induces B cell proliferation and immunoglobulin secretion. BAFF and its receptors are involved in the development of systemic lupus erythematosus and other B cell-associated autoimmune diseases.

ncbi gi num :

4585275

uniprot acc num :

Q9Y275

ncbi mol weight :

31,223 Da

ncbi pathways :

Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Intestinal Immune Network For IgA Production Pathway (128760); Intestinal Immune Network For IgA Production Pathway (128670); Rheumatoid Arthritis Pathway (200309); Rheumatoid Arthritis Pathway (200269)

ncbi summary :

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq]

uniprot summary :

BAFF: Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. Belongs to the tumor necrosis factor family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Cytokine; Cell cycle regulation; Apoptosis; Membrane protein, integral. Chromosomal Location of Human Ortholog: 13q32-q34. Cellular Component: extracellular space; perinuclear region of cytoplasm; cytoplasm; plasma membrane; integral to membrane. Molecular Function: protein binding; cytokine activity; tumor necrosis factor receptor binding; receptor binding. Biological Process: cell proliferation; B cell costimulation; B cell homeostasis; immunoglobulin secretion; T cell costimulation; positive regulation of cell proliferation; positive regulation of B cell proliferation; positive regulation of germinal center formation; positive regulation of T cell proliferation; immune response; signal transduction

size1 :

0.1 mg

price1 :

370 USD

more info or order :

MyBioSource product webpage