antibody

Anti-BACE (CT) Antibody

MBS194030

0.1 mg

370 USD

polyclonal

rabbit

nonconjugated

Antibody

Anti-BACE (CT) Antibody

BACE (CT)

Anti-BACE (CT); BACE/Asp2 (CT)

Rabbit

Anti-BACE (CT) [Rabbit antibody to peptide corresponding to aa 485-501 at the C-terminus of human BACE.]. This antibody recognizes human and mouse BACE (approx. 70 kD).

100 ug IgG in 200 ul PBS, pH 7.4, purified by immunoaffinity chromatography.

This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.

Immunoblot

Immunoblotting: use at 1:500-1:1,000 dilution. Positive control: Human brain tissue lysate.

Antigen: Peptide corresponding to aa 485- 501 of human BACE. This sequence differs from those of mouse and rat by one amino acid.

Stabilizer: None. Preservatives: 0.02% sodium azide. Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.

Neuroscience and Signal Transduction Antibodies

Accumulation of the amyloid- beta peptide (A beta ) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. A beta peptide is generated as a result of proteolytic cleavage of the beta -amyloid protein precursor (APP) at beta - and gamma -sites by two proteases. APP is first cleaved by beta - secretase to produce a soluble derivative of the protein and a membrane-anchored 99- amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for gamma -secretase to generate the 4 kD amyloid- beta peptide which is found in brains of patients with Alzheimer's disease. beta -secretase was recently identified and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). BACE/Asp2 is a transmembrane aspartic protease and colocalizes with APP.

0.1 mg

370 USD