catalog number :
MBS194029
products full name :
Anti-ASK1 Antibody
products short name :
ASK1 (CT)
products name syn :
Anti-ASK1 (CT); ASK1 (CT)
specificity :
Anti-ASK1 (CT) [Rabbit antibody to peptide corresponding to aa 1356-1375 of human ASK1.]. This antibody recognizes human ASK1 (155 kD).
form :
100 ug IgG in PBS, pH 7.4, purified by immunoaffinity chroma-tography.
storage stability :
This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.
tested application :
Immunoblot
app notes :
Immunoblotting : use at 1:500-1:1,000 dilution. Positive control: Whole cell lysate from SW1353 cells.
other info1 :
Antigen: Peptide corresponding to aa 1356-1375 of human ASK1. This peptide sequence is different from that of mouse in the last two amino acids.
other info2 :
Stabilizer: None. Preservatives: 0.02% sodium azide. Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.
products categories :
Apoptosis Antibodies
products description :
Mitogen-activated protein (MAP) kinase cascades are activated in response to various extracellular stimuli, including cytokines, growth factors, and environmental stresses. A novel MAP kinase kinase kinase (MAPKKK) was recently identified and designated ASK1 (apoptosis signal-regulating kinase 1) and MAPKKK5. ASK1 activates two different subgroups of MAPKK, MKK4 and MKK6, which in turn activate c-jun N-terminal kinase (JNK) and p36 MAP kinase. ASK1/MAPKKK5 is activated by TNFR and Fas through the interaction with members of the TRAF family and Fas-associated protein Daxx. Overexpression of ASK1 induces apoptotic cell death. A catalytically inactive form of ASK1 inhibits TNF?-induced apoptosis. ASK1 is expressed in a variety of human and mouse tissues.
ncbi pathways :
Focal Adhesion Pathway (83067); Focal Adhesion Pathway (478); MAPK Signaling Pathway (83048); MAPK Signaling Pathway (456); Salmonella Infection Pathway (375172); Salmonella Infection Pathway (375149)