product summary
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company name :
MyBioSource
product type :
antibody
product name :
Anti-ARC (NT) Antibody
catalog :
MBS194027
quantity :
0.1 mg
price :
370 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS194027
products type :
Antibody
products full name :
Anti-ARC (NT) Antibody
products short name :
ARC (NT)
products name syn :
Anti-ARC (NT); ARC (NT)
other names :
ARC; Activity-regulated cytoskeleton-associated protein; activity-regulated cytoskeleton-associated protein; activity-regulated cytoskeleton-associated protein; ARC/ARG3.1; Activity-regulated gene 3.1 protein homolog
other gene names :
ARC; ARC; Arg3.1; KIAA0278; ARC; KIAA0278
uniprot entry name :
ARC_HUMAN
host :
Rabbit
specificity :
Anti- ARC (NT) [Rabbit antibody to peptide corresponding to aa 2-18 of human ARC. Recognizes human, mouse, and rat ARC.]. This antibody recognizes human, mouse, and rat ARC (25 kD).
form :
100 ug IgG in PBS, pH 7.4, purified by immunoaffinity chromatography.
storage stability :
This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.
tested application :
Immunoblot
app notes :
Immunoblotting: use at 1:500 dilution. Positive control: Whole cell lysate of HeLa cells.
other info1 :
Antigen: Peptide corresponding to aa 2-18 of human ARC.
other info2 :
Stabilizer: None. Preservatives: 0.02% sodium azide. Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.
products categories :
Apoptosis Antibodies
products description :
Apoptosis is regulated by death domain (DD)- and/or caspase recruitment domain (CARD)-containing molecules and a caspase family of proteases. CARDcontaining cell death regulators include RAIDD, RICK, BCL10, Apaf-1, caspase-9, and caspase-2. A novel CARD domaincontaining protein was recently identified and designated ARC (apoptosis repressor with CARD). ARC interacts with caspase-2 and -8 and inhibits enzymatic activity of caspase-8. ARC suppresses apoptosis induced by cell death adapters FADD and TRADD and by cell death receptors Fas, TNFR-1, and DR3. The mRNA of ARC is primarily expressed in skeletal muscle and cardiac tissue.
ncbi gi num :
6319152
ncbi acc num :
AAF07185.1
uniprot acc num :
Q7LC44
ncbi mol weight :
45,316 Da
ncbi pathways :
Amphetamine Addiction Pathway (547607); Amphetamine Addiction Pathway (550546)
uniprot summary :
ARG3.1: Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. Belongs to the ARC/ARG3.1 family. Chromosomal Location of Human Ortholog: 8q24.3. Cellular Component: postsynaptic membrane; postsynaptic density; cytoplasm; plasma membrane; acrosome; dendritic spine; cell junction; endosome; actin cytoskeleton. Biological Process: anterior/posterior pattern formation; cell migration; regulation of cell morphogenesis; endocytosis; cytoskeleton organization and biogenesis; learning; regulation of neuronal synaptic plasticity; endoderm development
size1 :
0.1 mg
price1 :
370 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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