catalog number :
MBS194014
products full name :
Anti-Acinus (CT) Antibody
products short name :
Acinus (CP)
products name syn :
Anti-Acinus (CP); Acinus (CP)
specificity :
Anti-Acinus (CP) [Rabbit antibody to peptide corresponding to aa 307-322 of human Acinus S and aa 338-353 of human Acinus S'. Recognizes human and mouse Acinus.]. This antibody recognizes human and mouse Acinus (220 kD).
form :
100 ug IgG in PBS, pH 7.4, purified by immunoaffinity chromatography.
storage stability :
This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.
tested application :
Immunoblot
app notes :
Immunoblotting: use at 1:500-1:1,000 dilution. Positive control: Whole cell lysate from K562 cells.
other info1 :
Antigen: Peptide corresponding to aa 1065-1080 of human AcinusL, aa 307- 322 of human Acinus S and aa 338-353 of human AcinusS' which are identical to those of mouse Acinus. These sequences are located near the Cterminus of the cleaved active peptide p17.
other info2 :
Stabilizer: None. Preservatives: 0.02% sodium azide. Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.
products categories :
Apoptosis Antibodies
products description :
Chromatin condensation and nuclear fragmentation (CCNF) are the hallmark of apoptosis. CCNF is triggered by the activation of members of the caspase family, caspase-activated DNase, and several novel proteins including AIF and CIDE. A new inducer of chromatin condensation was recently identified and designated Acinus (for Apoptotic Chromatin Condensation Inducer in the Nucleus). Acinus is cleaved by caspase-3 and an additional unknown protease to generate a small active peptide, p17, which causes chromatin condensation in vitro when it is added to purfied nuclei. Acinus also induces apoptotic chromatin condensation in cells. Acinus is ubiquitously expressed. Three different spliced forms of Acinus have been identified in human and mouse and are designated AcinusL, AcinusS, and AcinusS'.