FPR1 Monoclonal Antibody | MyBioSource MBS190883 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

FPR1 Monoclonal Antibody

catalog :

MBS190883

quantity :

0.1 mg

price :

365 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

[NFPRb]

reactivity :

human

application :

western blot, immunocytochemistry

more info or order :

MyBioSource product webpage

image

image 1 :

image 2 :

product information

catalog number :

MBS190883

products type :

Antibody

products full name :

FPR1 Monoclonal Antibody

products short name :

[FPR1]

products name syn :

[Anti-FPR1]

other names :

[fMet-Leu-Phe receptor; fMet-Leu-Phe receptor; fMet-Leu-Phe receptor; formyl peptide receptor 1; N-formyl peptide receptor; FPR; N-formylpeptide chemoattractant receptor]

products gene name :

[FPR1]

other gene names :

[FPR1; FPR1; FPR; FMLP; fMLP receptor; FPR]

uniprot entry name :

FPR1_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

[NFPRb]

host :

Mouse

sequence length :

350

specificity :

This antibody recognizes human FPR1 at the cytoplasmic C-terminal aa 338- STLPSAEVELQAK-350. It is sensitive to C-terminal tail phosphorylation. It does not recognize human FPR2.

purity :

Protein G purified

form :

100ug protein G-purified antibody in PBS pH 7.4

concentration :

1.06 mg/ml

storage stability :

This product is stable for at least one (1) year at -20°C to -70°C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.

tested application :

Immunoblotting (IB), Immunofluorescence (IF)

app notes :

Immunoblotting: Use at 1-5ug/ml. Immunofluorescence: Use at 10ug/ml. These are recommended concentrations. Enduser should determine optimal concentrations for their application.

image1 heading :

Immunoblotting

image2 heading :

Immunofluorescence

other info1 :

Antigen: His-tagged recombinant FPR1 (human neutrophil N-formyl peptide receptor 1) expressed in and purified from Sf9 cells. Appearance: Clear liquid

other info2 :

Dilution Instructions: Dilute in PBS or medium that is identical to that used in the assay system.

products categories :

Growth Factors/Cytokines/Receptor Antibodies

products description :

Formyl peptide receptors (FPR) are G protein-coupled receptors that are activated by different agonists included N-formylated peptides originating from bacteria and mitochondria. In humans, the FPR family includes the high affinity FPR1, the low affinity FPR2/ALX (previously known as FPRL1 or ALX) and FPR3. Human FPR1 is important for phagocyte chemotaxis, superoxide production, and degranulation, and helps direct phagocytes to sites of infection. Functional FPR1expression has been demonstrated on fibroblasts, bone marrow mesenchymal stem cells, A549 lung cells, HEP-G2 hepatoma cells, and on several types of epithelial cells.

ncbi gi num :

300863094

ncbi acc num :

NP_001180235.1

ncbi gb acc num :

NM_001193306.1

ncbi mol weight :

38,446 Da

ncbi pathways :

Class A/1 (Rhodopsin-like Receptors) Pathway (1269545); Formyl Peptide Receptors Bind Formyl Peptides And Many Other Ligands Pathway (1269551); G Alpha (i) Signalling Events Pathway (1269576); GPCR Downstream Signaling Pathway (1269574); GPCR Ligand Binding Pathway (1269544); GPCRs, Class A Rhodopsin-like Pathway (198886); Neuroactive Ligand-receptor Interaction Pathway (83053); Neuroactive Ligand-receptor Interaction Pathway (462); Peptide GPCRs Pathway (920907); Peptide GPCRs Pathway (198897)

ncbi summary :

This gene encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein coupled receptor 1 family. The protein mediates the response of phagocytic cells to invasion of the host by microorganisms and is important in host defense and inflammation.[provided by RefSeq, Jul 2010]

uniprot summary :

FPR1: High affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1. Chromosomal Location of Human Ortholog: 19q13.4. Cellular Component: endosome; integral to membrane; plasma membrane. Molecular Function: N-formyl peptide receptor activity; protein binding; RAGE receptor binding; receptor activity. Biological Process: activation of MAPK activity; cell motility; chemotaxis; G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); nitric oxide mediated signal transduction; signal transduction

size1 :

0.1 mg

price1 :

365 USD

more info or order :

MyBioSource product webpage