product summary
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company name :
MyBioSource
product type :
antibody
product name :
Anti-Inositol hexakisphosphate kinase 2 (IP6K2) Monoclonal Antibody
catalog :
MBS190567
quantity :
0.1 mg
price :
340 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
4F10
application :
western blot
more info or order :
product information
catalog number :
MBS190567
products type :
Antibody
products full name :
Anti-Inositol hexakisphosphate kinase 2 (IP6K2) Monoclonal Antibody
products short name :
IP6K2
products gene name :
IP6K2
clonality :
Monoclonal
isotype :
IgG2b
clone :
4F10
host :
Mouse
reactivity :
Human
specificity :
IP6K2. This antibody recognizes human IP6K2.
form :
100ug in PBS, pH 7.4, purified by Protein G affinity chromatography
storage stability :
This antibody is stable for at least one (1) year at -20 degree C. Avoid repeated freezing and thawing.
tested application :
Immunoblot
app notes :
Immunoblotting: A band of ~49 kDa is detected. User should determine optimal concentrations for their application. Positive control: purified human IP6K2 or NIH-OVCAR-3 cells after treatment with interferon (IFN)-beta.
other info1 :
Antigen: Full-length recombinant human IP6K2. Preservative: None
other info2 :
Dilution Instructions: Dilute in PBS or medium which is identical to that used in the assay system.
products description :
Inositol hexakisphosphate kinase 2 (IP6K2) catalyzes the production of diphosphoinositol pentakisphosphate (IP7) and has a role as a proapoptotic gene sensitizing cancer cells to apoptosis by cell stressors and anticancer drugs all of which depend on IP6K2 catalytic activity. IP6K2 is located in the 3p21.31 chromosomal region, which often undergoes allele loss in a variety of human cancers. Some heat shock proteins, especially Hsp90, can be antiapoptotic and the targets of anticancer drugs. Hsp90 binds IP6K2 and inhibits its catalytic activity. Drugs and selective mutations that abolish HSP90-IP6K2 binding elicit activation of IP6K2, leading to cell death. Thus, the prosurvival actions of HSP90 reflect the inhibition of IP6K2, suggesting that selectively blocking this interaction could provide effective and safer modes of chemotherapy.
products references :
Morrison, BH et al. 2002 Oncogene 21:1882-1889.
size1 :
0.1 mg
price1 :
340 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.
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