product summary
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company name :
MyBioSource
product type :
antibody
product name :
DOG1 Monoclonal Antibody
catalog :
MBS190561
quantity :
0.1 mg
price :
365 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
DOG1.1
application :
immunohistochemistry
more info or order :
product information
catalog number :
MBS190561
products type :
Antibody
products full name :
DOG1 Monoclonal Antibody
products short name :
DOG1
other names :
DOG1
products gene name :
DOG1
clonality :
Monoclonal
isotype :
lgG1
clone :
DOG1.1
host :
Mouse
reactivity :
Human
sequence positions :
904-986
specificity :
DOG1. This antibody recognizes human DOG1.
form :
100 ug Protein G-purified antibody in PBS, pH 7.4.
storage stability :
This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freezethaw cycles.
tested application :
Immunohistochemistry
app notes :
Immunohistochemistry: Use at 1-10ug/ml on paraffin-embedded samples. Antigen retrieval solution: 10mM citrate, pH 6 (boil slides by microwaving in antigen retrieval solution for 12 minutes). User should determine optimal concentrations for their applications.
other info1 :
Antigen: Synthetic peptide corresponding to aa 904-986 of human DOG1 (accession no. Q5XXA6). Preservative: None. Available on request.
other info2 :
Dilution Instructions: Dilute in PBS or medium which is identical to that used in the assay system.
products description :
DOG1 (Discovered on GIST1), also known as TMEM16A and ANO1, has emerged in recent years as a promising biomarker for gastrointestinal stromal tumors (GIST). It was originally discovered through microarray expression profiling analysis as a gene that is highly expressed in GIST, and subsequent immunohistochemical studies have shown its use in its diagnosis. DOG1 antibodies are more sensitive than KIT antibodies in detecting tumors of gastric origin, tumors with epithelioid morphology, and tumors harboring PDGFRA mutation. DOG1 immunoreactivity is rarely observed in other mesenchymal and nonmesenchymal tumor types. These results support the use of DOG1 as a biomarker for GIST.
products references :
Espinosa I et al. 2008 Am J Surg Pathol 32: 210-218. Lee CH et al. 2010 Adv Anat Pathol 17: 222-232.
ncbi gi num :
323099808
ncbi pathways :
Focal Adhesion Pathway 83067!!Focal Adhesion Pathway 478!!MAPK Signaling Pathway 83048!!MAPK Signaling Pathway 456!!Salmonella Infection Pathway 375172!!Salmonella Infection Pathway 375149
size :
0.1 mg
price :
365 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.
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