Anti-Cav beta 2 Ca+2 Channel Monoclonal Antibody | MyBioSource MBS190548 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-Cav beta 2 Ca+2 Channel Monoclonal Antibody

catalog :

MBS190548

quantity :

0.1 mg

price :

395 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

S8B-1

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS190548

products type :

Antibody

products full name :

Anti-Cav beta 2 Ca+2 Channel Monoclonal Antibody

products short name :

Cav-beta 2 Ca+2 Channel

other names :

voltage-dependent L-type calcium channel subunit beta-2; Voltage-dependent L-type calcium channel subunit beta-2; voltage-dependent L-type calcium channel subunit beta-2; CAB2; calcium channel voltage-dependent subunit beta 2; calcium channel, voltage-dependent, beta 2 subunit; Calcium channel voltage-dependent subunit beta 2

other gene names :

Cacnb2; Cacnb2; Cacnlb2; Cacnlb2

uniprot entry name :

CACB2_RAT

clonality :

Monoclonal

isotype :

IgG1

clone :

S8b-1

host :

Mouse

reactivity :

Human, mouse, rat

sequence positions :

189-205

specificity :

Cav beta 2 Ca+2 Channel. This antibody recognizes human, mouse, and rat Cavbeta2. It does not cross-react with Cav beta1, Cav beta3, or Cav beta4.

form :

100ug in PBS, pH 7.4; 50% glycerol, 0.09% sodium azide. Purified by Protein G affinity chromatography.

storage stability :

This antibody is stable for at least one (1) year at -20 degree C. Avoid repeated freezing and thawing.

tested application :

Immunoblot; Immunohistochemistry; Immunocytochemistry; Immunofluorescence

app notes :

Immunoblotting: use at 1-10ug/ml. A band of ~78kDa is detected. Immunohistochemistry and Immunocytochemistry: use at 0.1-1ug/ml. Immunofluorescence: use at 1-10ug/ml. These are recommended concentrations. User should determine optimal concentrations for their application. Positive control: Rat brain lysate

other info1 :

Antigen: Synthetic peptide corresponding to aa 189-205 of rat Cavbeta2 (RSPKPSANSVTSPHSKE) (accession no.NP_446303).

other info2 :

Dilution Instructions: Dilute in PBS or medium which is identical to that used in the assay system.

products description :

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. Cavbeta subunits are involved in the transport of the pore-forming alpha1 subunit to the plasma membrane. They also shield an ER Retention signal on the alpha1 subunit, thereby guiding the poreforming subunit to the target membrane.

ncbi gi num :

16758716

ncbi acc num :

NP_446303.1

ncbi gb acc num :

NM_053851.1

uniprot acc num :

Q8VGC3

ncbi mol weight :

73,226 Da

ncbi pathways :

Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (117251); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (116129); Cardiac Muscle Contraction Pathway (93346); Cardiac Muscle Contraction Pathway (93992); Depolarization Of The Presynaptic Terminal Triggers The Opening Of Calcium Channels Pathway (368673); Diabetes Pathways (368509); Dilated Cardiomyopathy Pathway (121476); Dilated Cardiomyopathy Pathway (121285); Hypertrophic Cardiomyopathy (HCM) Pathway (114014); Hypertrophic Cardiomyopathy (HCM) Pathway (106591)

ncbi summary :

auxillary subunit of the L-type Ca(2+) channel [RGD]

uniprot summary :

CACNB2: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. Defects in CACNB2 are the cause of Brugada syndrome type 4 (BRGDA4). A heart disease characterized by the association of Brugada syndrome with shortened QT intervals. Brugada syndrome is a tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset. Belongs to the calcium channel beta subunit family. 8 isoforms of the human protein are produced by alternative splicing. Protein type: Channel, calcium. Cellular Component: voltage-gated calcium channel complex; sarcolemma. Molecular Function: voltage-gated calcium channel activity; protein domain specific binding; calcium channel regulator activity; high voltage-gated calcium channel activity; phosphoprotein binding; protein kinase binding. Biological Process: synaptic transmission; visual perception; calcium ion transport; positive regulation of calcium ion transport; neuromuscular junction development

size1 :

0.1 mg

price1 :

395 USD

more info or order :

MyBioSource product webpage