catalog number : 
MBS190535
products full name : 
Anti-HCN1 Cyclic Nucleotide-Gated Channel Monoclonal Antibody
products short name : 
HCN1 Cyclic nucleotide-gated Channel
other names : 
hyperpolarization-activated cyclic nucleotide-gated cation channel 1; hyperpolarization-activated cyclic nucleotide-gated cation channel 1
reactivity : 
Human, mouse, rat
sequence positions : 
778-910
specificity : 
HCN1 Cyclic nucleotide-gated Channel. This antibody recognizes human, mouse, and rat HCN1. It does not cross-react with HCN2.
form : 
100ug in PBS, pH 7.4; 50% glycerol, 0.09% sodium azide. Purified by Protein G affinity chromatography
storage stability : 
This antibody is stable for at least one (1) year at -20 degree C. Avoid repeated freezing and thawing.
tested application : 
Immunoblot; Immunohistochemistry; Immunocytochemistry; Immunofluorescence
app notes : 
Immunoblotting: use at 1-10ug/ml. A band of ~100kDa is detected. Immunohistochemistry and Immunocytochemistry: use at 0.1-1 ug/ml. Immunofluorescence: use at 1-10ug/ml. These are recommended concentrations. User should determine optimal concentrations for their application. Positive control: Rat brain lysate
other info1 : 
Antigen: Fusion protein aa 778-910 (C-terminus) of rat HCN! (accession number Q9JKBO).
other info2 : 
Dilution Instructions: Dilute in PBS or medium which is identical to that used in the assay system.
products description : 
Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. Hyperpolarization-activated cation channels of the HCN gene family, such as HCN1, play a crucial role in the regulation of cell excitability. They contribute to spontaneous rhythmic activity in the heart and brain.
ncbi acc num : 
NP_001117790.1
ncbi gb acc num : 
NM_001124318.1