Glypican-1 Monoclonal Antibody | MyBioSource MBS190484 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Glypican-1 Monoclonal Antibody

catalog :

MBS190484

quantity :

0.1 mg

price :

350 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

9.00E+09

reactivity :

human

application :

western blot, ELISA

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS190484

products type :

Antibody

products full name :

Glypican-1 Monoclonal Antibody

products short name :

Glypican-1

products name syn :

Glypican-1

other names :

glypican-1; Glypican-1; glypican-1; OTTHUMP00000164497; OTTHUMP00000201548; glypican proteoglycan 1; glypican 1

other gene names :

GPC1; GPC1; FLJ38078; glypican

uniprot entry name :

GPC1_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

9.00E+09

host :

Mouse

specificity :

This antibody recognizes native and recombinant human and mouse glypican-1.

form :

100 ug Protein G-purified antibody in PBS, pH 7.4.

storage stability :

This antibody is stable for at least one (1) year at -20 degree C . Avoid multiple freeze-thaw cycles.

tested application :

ELISA, Immunoblot, Immunoflourescence

app notes :

ELISA: at 1-5ug/ml will detect recombinant glypican-1 on the solid phase at 200ng/well. Immunoblotting: at 1-10ug/ml, a band of approx. 64 kDa is detected in normal mouse brain.

other info1 :

Antigen: Recombinant full-length human glypican-1.

other info2 :

Stabilizer: None. Preservatives: None. Available on request. Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.

products categories :

Cancer Research Products

products description :

Glypican-1 is a widely expressed, GPI anchored, cell surface proteoglycan that has been reported to be important in cellular adhesion and migration. Glypican-1 also functions as an accessory molecule for signaling receptors. Glypican-1 is overexpressed in human gliomas and pancreatic ductal cell carcinomas. Expression of glypican-1 is associated with the aggressive behavior of tumor cells in vitro and in vivo.

ncbi gi num :

167001141

ncbi acc num :

NP_002072.2

ncbi gb acc num :

NM_002081.2

uniprot acc num :

P35052

ncbi mol weight :

61,680 Da

ncbi pathways :

Activation Of Rac Pathway (119530); Axon Guidance Pathway (105688); Glypican 1 Network Pathway (138010); Glypican Pathway (138083); Inactivation Of Cdc42 And Rac Pathway (119529); Role Of Abl In Robo-Slit Signaling Pathway (119531); Signaling By Robo Receptor Pathway (119527)

ncbi summary :

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. [provided by RefSeq]

uniprot summary :

GPC1: Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination. May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling. Associates (via the heparan sulfate side chains) with fibrillar APP-beta amyloid peptides in primitive and classic amyloid plaques and may be involved in the deposition of these senile plaques in the Alzheimer disease (AD) brain. Misprocessing of GPC1 is found in fibroblasts of patients with Niemann-Pick Type C1 disease. This is due to the defective deaminative degradation of heparan sulfate chains. Belongs to the glypican family. Protein type: Motility/polarity/chemotaxis; Membrane protein, GPI anchor; Extracellular matrix. Chromosomal Location of Human Ortholog: 2q35-q37. Cellular Component: proteinaceous extracellular matrix; lysosomal lumen; extracellular space; Golgi lumen; integral to plasma membrane; plasma membrane; endosome; lipid raft. Molecular Function: heparan sulfate proteoglycan binding; copper ion binding; fibroblast growth factor binding; laminin binding. Biological Process: chondroitin sulfate metabolic process; Schwann cell differentiation; axon guidance; myelin formation; glycosaminoglycan biosynthetic process; phototransduction, visible light; glycosaminoglycan catabolic process; heparan sulfate proteoglycan catabolic process; glycosaminoglycan metabolic process; negative regulation of fibroblast growth factor receptor signaling pathway; carbohydrate metabolic process; pathogenesis; retinoid metabolic process

size1 :

0.1 mg

price1 :

350 USD

more info or order :

MyBioSource product webpage