KDEL Receptor Monoclonal Antibody | MyBioSource MBS190472 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

KDEL Receptor Monoclonal Antibody

catalog :

MBS190472

quantity :

0.1 mg

price :

385 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

KR-10

reactivity :

human

application :

western blot, immunocytochemistry, immunoprecipitation

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS190472

products type :

Antibody

products full name :

KDEL Receptor Monoclonal Antibody

products short name :

KDEL Receptor

products name syn :

KDEL Receptor

other names :

KDEL receptor; ER lumen protein retaining receptor 1; ER lumen protein retaining receptor 1; KDEL receptor 1; putative MAPK-activating protein PM23; KDEL endoplasmic reticulum protein retention receptor 1; KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1; KDEL endoplasmic reticulum protein retention receptor 1; KDEL receptor 1; Putative MAPK-activating protein PM23

other gene names :

KDELR1; KDELR1; ERD2; HDEL; PM23; ERD2.1; ERD2.1

uniprot entry name :

ERD21_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

KR-10

host :

Mouse

specificity :

KDEL Receptor [Mouse monoclonal antibody recognizes KDEL receptor of multiple species.]. This antibody recognizes human, monkey, mouse, rat, hamster, rabbit, porcine, bovine, ovine, canine, chicken, Drosophila, and Xenopus KDEL receptor.

form :

100ug purified antibody in PBS, pH 7.4.

storage stability :

Store frozen product at or below -20 degree C.Thawed product may be stored for 2-4 weeks at 4 degree C. For optimal storage, aliquot to smaller portions and store at -20 degree C to -70oC. Avoid repeated freeze/thaw cycles.

tested application :

Western Blot, Immunocytochemistry, Immunoprecipitation

app notes :

Western Blot: Use at 1:1,000 dilution. A band of approx. 25 kD is detected. Immunocytochemistry: Use at 1:1,000 dilution. Immunoprecipitation: Use at 1:500 dilution.

other info1 :

Antigen: Peptide corresponding to aa 192-212 of bovine KDEL receptor conjugated to KLH.

other info2 :

Preservatives: None. Available on request. Dilutions Instructions: Dilute in PBS or medium that is identical to that used in the assay system.

products categories :

Neuroscience and Signal Transduction Antibodies

products description :

KDEL receptor, an integral membrane protein, facilitates the retrieval of soluble endoplasmic reticulum (ER) luminal proteins bearing the four amino acid retention motif KDEL from the Golgi apparatus. The sequence of KDEL receptor is very similar to that of the yeast protein Erd2p, a receptor for proteins containing the tetrapeptide HDEL, the yeast ER retention signal. KDEL receptors interact with GAP (GTPase-activating protein) of ARF1, a small GTP-binding protein involved in COPI-dependent vesicle transport. KDEL receptors may recruit cytosolic ARF1 to membranes and regulate vesicle budding.

ncbi gi num :

34031

ncbi acc num :

CAA39371.1

uniprot acc num :

P24390

ncbi mol weight :

24,542 Da

ncbi pathways :

Vibrio Cholerae Infection Pathway (83101); Vibrio Cholerae Infection Pathway (513)

ncbi summary :

Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, which is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. The protein encoded by this gene was the first member of the family to be identified, and it encodes a protein structurally and functionally similar to the yeast ERD2 gene product. [provided by RefSeq]

uniprot summary :

KDELR1: Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L. Belongs to the ERD2 family. Protein type: Endoplasmic reticulum; Membrane protein, multi-pass; Membrane protein, integral. Chromosomal Location of Human Ortholog: 19q13.3. Cellular Component: COPI coated vesicle membrane; endoplasmic reticulum membrane; ER-Golgi intermediate compartment membrane; cis-Golgi network; membrane; ER-Golgi intermediate compartment; integral to membrane. Molecular Function: KDEL sequence binding. Biological Process: vesicle-mediated transport; intracellular protein transport; protein retention in ER

size1 :

0.1 mg

price1 :

385 USD

more info or order :

MyBioSource product webpage