Tumor Necrosis Factor alpha Monoclonal Antibody | MyBioSource MBS190459 product information

product summary

request information :

company name :

MyBioSource

product type :

antibody

product name :

Tumor Necrosis Factor alpha Monoclonal Antibody

catalog :

MBS190459

quantity :

0.2 mg

price :

305 USD

clonality :

monoclonal

host :

mouse

reactivity :

human

application :

immunohistochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS190459

products type :

Antibody

products full name :

Tumor Necrosis Factor alpha Monoclonal Antibody

products short name :

Tumor Necrosis Factor Alpha

products name syn :

Anti-Tumor Necrosis Factor Alpha; Tumor Necrosis Factor a

other names :

tumor necrosis factor; Tumor necrosis factor; tumor necrosis factor; TNF-a; cachectin; APC1 protein; OTTHUMP00000029281; TNF, monocyte-derived; TNF, macrophage-derived; TNF superfamily, member 2; tumor necrosis factor alpha; tumor necrosis factor-alpha; tumor necrosis factor ligand superfamily member 2; tumor necrosis factor; Cachectin; TNF-alpha; Tumor necrosis factor ligand superfamily member 2

other gene names :

TNF; TNF; DIF; TNFA; TNFSF2; TNF-alpha; TNFA; TNFSF2

uniprot entry name :

TNFA_HUMAN

clonality :

Monoclonal

isotype :

IgG1

host :

Mouse

specificity :

Anti-Tumor Necrosis Factor Alpha [Murine Mabs recognize human TNF a. 21301 and 21302 inhibit biological activity (3 clones).]

form :

200 ug Protein A-purified antibody in PBS, pH 7.4.

storage stability :

These antibodies are stable for at least one (1) year at -20 degree C to -70 degree C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles

tested application :

Immunoassay, Immunohistochemistry

app notes :

These antibodies may be used in immunoassays or in immunohistochemistry to detect and/or quantitate TNF alpha . 21301 and 21302 may be used in biological assays to inhibit activity of TNF alpha . Other applications are under investigation

other info1 :

Antigen: Recombinant human TNF alpha .

other info2 :

Stabilizer: None. Preservatives: 0.1% sodium azide. Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.

products categories :

Hormone and Serum Protein Antibodies

ncbi gi num :

25952111

ncbi acc num :

NP_000585.2

ncbi gb acc num :

NM_000594.2

uniprot acc num :

P01375

ncbi mol weight :

25,644 Da

ncbi pathways :

Adipocytokine Signaling Pathway 83093!!Adipocytokine Signaling Pathway 505!!Adipogenesis Pathway 198832!!African Trypanosomiasis Pathway 194384!!African Trypanosomiasis Pathway 194323!!Allograft Rejection Pathway 83123!!Allograft Rejection Pathway 535!!Alzheimer's Disease Pathway 83097!!Alzheimer's Disease Pathway 509!!Amoebiasis Pathway 167324

ncbi summary :

This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq]

uniprot summary :

Function: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Subunit structure: Homotrimer. Subcellular location: Cell membrane; Single-pass type II membrane protein. Tumor necrosis factor, soluble form: Secreted. Post-translational modification: The soluble form derives from the membrane form by proteolytic processing.The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1. Ref.18 Ref.19O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid. Ref.15. Polymorphism: Genetic variations in TNF influence susceptibility to hepatitis B virus (HBV) infection [. MIM:610424]. Involvement in disease: Genetic variations in TNF are a cause of susceptibility psoriatic arthritis (PSORAS) [. MIM:607507]. PSORAS is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoidlike pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis). Sequence similarities: Belongs to the tumor necrosis factor family. Sequence caution: The sequence AAF71992.1 differs from that shown. Reason: Frameshift at positions 91 and 157. The sequence CAA75070.1 differs from that shown. Reason: Erroneous gene model prediction.

size :

0.2 mg

price :

305 USD

more info or order :

MyBioSource product webpage