Thyroglobulin (T3/T4) Monoclonal Antibody | MyBioSource MBS190442 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Thyroglobulin (T3/T4) Monoclonal Antibody

catalog :

MBS190442

quantity :

1 mg

price :

370 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS190442

products type :

Antibody

products full name :

Thyroglobulin (T3/T4) Monoclonal Antibody

products short name :

Thyroglobulin

products name syn :

Anti-Thyroglobulin; Thyroglobulin

other names :

thyroglobulin; Thyroglobulin; thyroglobulin; OTTHUMP00000227159; thyroglobulin

other gene names :

TG; TG; TGN; AITD3

uniprot entry name :

THYG_HUMAN

clonality :

Monoclonal

isotype :

IgG1

host :

Mouse

sequence length :

2768

specificity :

Anti-Thyroglobulin Murine MAbs recognize human thyroglobulin. Recognize T3 and T4.

form :

1 ml ascites or 1 mg Protein G-purified antibody in PBS, pH 7.4

storage stability :

These antibodies are stable for at leastone (1) year at -20 degree C to -70 degree C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.

tested application :

Immunoassay

app notes :

These antibodies may be used inimmunoassays to detect and quantitatethyroglobulin. Other applications areunder investigation.

other info1 :

Antigen: Purified human thyroglobulin. Activity: Ig mg/ml : 11.4. ELISA Titer**: 1: 51,200. (Note: * Determined by radial immunodiffusionfor several lots of ascites. **ELISA is an indirect assay againstthyroglobulin on the solid phase. Titers represent endpoint dilutions that achieveabsorbance values >= 0.1.)

other info2 :

Stabilizer: None. Preservatives: None. Available on request. Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.

products categories :

Hormone and Serum Protein Antibodies

ncbi gi num :

37174

ncbi acc num :

CAA29104.1

uniprot acc num :

P01266

ncbi mol weight :

304,790 Da

ncbi pathways :

Autoimmune Thyroid Disease Pathway (83121); Autoimmune Thyroid Disease Pathway (533)

ncbi summary :

Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq]

uniprot summary :

TG: Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). Defects in TG are the cause of thyroid dyshormonogenesis 3 (TDH3). A disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases. Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3 (AITD3). AITDs including Graves disease (GD) and Hashimoto thyroiditis (HT), are among the most common human autoimmune diseases. They are complex diseases, which are caused by an interaction between susceptibility genes and nongenetic factors, such as infection. Belongs to the type-B carboxylesterase/lipase family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 8q24. Cellular Component: extracellular space; extracellular region. Molecular Function: hormone activity. Biological Process: regulation of myelination; iodide transport; thyroid gland development; hormone biosynthetic process; signal transduction; thyroid hormone metabolic process. Disease: Thyroid Dyshormonogenesis 3; Autoimmune Thyroid Disease, Susceptibility To, 3

size1 :

1 mg

price1 :

370 USD

more info or order :

MyBioSource product webpage