catalog number :
MBS190441
products full name :
Thymidine Kinase Monoclonal Antibody
products short name :
Thymidine Kinase
products name syn :
Anti-Thymidine Kinase; Thymidine Kinase
other names :
thymidine kinase; thymidine kinase
other gene names :
LOC100301667; LOC100301667
specificity :
Anti-Thymidine Kinase [Murine MAb to human thymidine kinase]. This antibody specifically recognizes human thymidine kinase.
form :
200 ug Protein G-purified antibody in PBS, pH 7.4.
storage stability :
This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.
tested application :
ELISA, Immunoblot
app notes :
Immunoblotting: antibody at 10 ug/ml will recognize TK in 5, 10, or 20 ug lysates of cells that express TK. ELISA: use antibody at 2-5 ug/ml (optimized for TK on solid phase at 10 ug/ml).
other info1 :
Antigen: 5'-His-tagged recombinant human thymidine kinase.
other info2 :
Stabilizer: None. Preservatives: None. Available on request. Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.
products categories :
Cancer Research Products
products description :
Thymidine kinase (TK) belongs to a group of enzymes such as dihydrofolate reductase, thymidylate synthase, and DNA polymerase that are involved in DNA synthesis and precursor production. High levels of these enzymes are present in proliferating cells, and low levels are found in resting cells, due to multiple regulatory mechanisms that ensure exclusive expression of these enzymes in replicating cells. TK is responsible for catalyzing the phosphorylation of thymidine, which functions as a part of the pyrimidine salvage pathway involved in DNA synthesis. The activities of enzymes such as TK are essential for the activation of several chemotherapeutically important nucleoside analogues that are administered as prodrugs.
ncbi acc num :
NP_001153968.1
ncbi gb acc num :
NM_001160496.1