antibody

Progesterone Receptor Monoclonal Antibody

MBS190386

0.1 mL

410 USD

monoclonal

mouse

nonconjugated

Antibody

Progesterone Receptor Monoclonal Antibody

Progesterone Receptor

Anti-Progesterone Receptor; Progesterone Receptor

progesterone receptor; Progesterone receptor; progesterone receptor; OTTHUMP00000236114; OTTHUMP00000236115; OTTHUMP00000236117; OTTHUMP00000236119; nuclear receptor subfamily 3 group C member 3; progesterone receptor; Nuclear receptor subfamily 3 group C member 3

PGR; PGR; PR; NR3C3; NR3C3

PRGR_HUMAN

Monoclonal

IgG2a kappa

Mouse

933

Anti-Progesterone Receptor [Murine MAb to fusion protein corresponding to aa 1-101 of human progesterone receptor, a member of the steroid family of nuclear receptors.]. This antibody recognizes human progesterone receptor (PgR), a member of the steroid family of nuclear receptors. PgR is found as a 94 kD protein (Form A) or a 120 kD protein (Form B). Binding of progesterone to its receptor results in a conformational change that allows dimerization and binding of the receptor to progesterone response elements and activated transcription. When bound to DNA, PgR can positively or negatively regulate gene transcription.

100 ug Protein G-purified antibody in PBS, pH 7.4

This antibody is stable for at least one (1) year at -70 degree C. Avoid multiple freeze thaw cycles.

Immunoblot

Immunoblotting: use at 1-5 ug/ml. Positive controls: MCF7 cells or recombinant protein.

Antigen: 6-His fusion protein containing the region encoding aa 1-101of human progesterone receptor expressed in E. coli

Stabilizer: None. Preservatives: None. Available on request. Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.

Cancer Research Products

189935

AAA60081.1

P06401

98,981 Da

Cellular Roles Of Anthrax Toxin Pathway (138076); Gene Expression Pathway (105937); Generic Transcription Pathway (105938); Nuclear Receptor Transcription Pathway (105979); Nuclear Receptors Pathway (198848); Oocyte Meiosis Pathway (126909); Oocyte Meiosis Pathway (126872); Ovarian Infertility Genes Pathway (198801); Progesterone-mediated Oocyte Maturation Pathway (119304); Progesterone-mediated Oocyte Maturation Pathway (503)

This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq]

PR: a nuclear hormone receptor and transcription factor. Regulates gene expression and affects cellular proliferation and differentiation in target tissues. Two splice-variant isoforms have been described. Protein type: Nuclear receptor; DNA-binding. Chromosomal Location of Human Ortholog: 11q22-q23. Cellular Component: nucleoplasm; mitochondrial outer membrane. Molecular Function: protein binding; ligand-dependent nuclear receptor activity; enzyme binding; DNA binding; zinc ion binding; steroid hormone receptor activity; steroid binding; receptor binding. Biological Process: transcription initiation from RNA polymerase II promoter; progesterone receptor signaling pathway; cell-cell signaling; epithelial cell maturation; steroid hormone mediated signaling; gene expression; positive regulation of transcription from RNA polymerase II promoter; signal transduction; ovulation from ovarian follicle; regulation of epithelial cell proliferation. Disease: Progesterone Resistance

0.1 mL

410 USD