catalog number :
MBS190364
products full name :
Parathyroid Hormone Monoclonal Antibody
products short name :
Parathyroid Hormone
products name syn :
Anti-Parathyroid Hormone; Parathyroid Hormone
other names :
Parathyroid hormone; Parathyroid hormone; parathyroid hormone; parathyrin; parathormone; OTTHUMP00000230966; parathyroid hormone 1; parathyroid hormone; Parathormone; Parathyrin
other gene names :
PTH; PTH; PTH1
uniprot entry name :
PTHY_HUMAN
specificity :
Anti-Parathyroid Hormone [Two murine MAbs recognize different epitopes at the C-terminus and N-terminus of human PTH.]. Recognizes an epitope located at the C-terminus of human parathyroid hormone (aa 53-83)
form :
200 ug Protein A-purified antibody in PBS, pH 7.4
storage stability :
This antibody is stable for at least one (1) year at -20 degree C to -70 degree C. Avoid multiple freeze thaw cycles.
tested application :
ELISA, Immunohistochemistry
app notes :
These antibodies may be used in ELISA and immunohistochemistry to detect human parathyroid hormone.
other info1 :
Antigen: Purified human parathyroid hormone.
other info2 :
Stabilizer: None. Preservatives: 0.1% sodium azide. Dilutions Instructions: Dilute in PBS or medium that is identical to that used in the assay system.
products categories :
Hormone and Serum Protein Antibodies
ncbi acc num :
AAH96144.1
ncbi mol weight :
12,861 Da
ncbi pathways :
Class B/2 (Secretin Family Receptors) Pathway 106378!!Endochondral Ossification Pathway 198812!!G Alpha (s) Signalling Events Pathway 119549!!GPCR Downstream Signaling Pathway 119548!!GPCR Ligand Binding Pathway 161020!!Osteoblast Signaling Pathway 198842!!Signaling By GPCR Pathway 106356
ncbi summary :
The protein encoded by this gene is a hormone secreted by parathyroid cells. This hormone elevates blood Ca2+ level by dissolving the salts in bone and preventing their renal excretion. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH). [provided by RefSeq]
uniprot summary :
Function: PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells. Ref.13. Subunit structure: Interacts with PTH1R (via N-terminal extracellular domain). Ref.19. Subcellular location: Secreted. Involvement in disease: Defects in PTH are a cause of familial isolated hypoparathyroidism (FIH) [. MIM:146200]; also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism. Ref.20 Ref.21 Ref.22. Sequence similarities: Belongs to the parathyroid hormone family.