Myelin Basic Protein Monoclonal Antibody | MyBioSource MBS190340 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Myelin Basic Protein Monoclonal Antibody

catalog :

MBS190340

quantity :

0.5 mg

price :

480 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS190340

products type :

Antibody

products full name :

Myelin Basic Protein Monoclonal Antibody

products short name :

Myelin Basic Protein

products name syn :

Anti-Myelin Basic Protein; Myelin Basic Protein

other names :

myelin basic protein; Myelin basic protein; Golli-MBP; myelin basic protein; myelin A1 protein; OTTHUMP00000163774; OTTHUMP00000163775; OTTHUMP00000174383; OTTHUMP00000174384; OTTHUMP00000174385; OTTHUMP00000174386; OTTHUMP00000174387; OTTHUMP00000174388; OTTHUMP00000174389; OTTHUMP00000174390; OTTHUMP00000233691; myelin membrane encephalitogenic protein; myelin basic protein; Myelin A1 protein; Myelin membrane encephalitogenic protein

other gene names :

MBP; MBP; MGC99675

uniprot entry name :

MBP_HUMAN

clonality :

Monoclonal

isotype :

IgG2b

host :

Mouse

sequence length :

304

specificity :

Anti-Myelin Basic Protein [Murine MAb recognizes residues 130-136 in myellin basic protein of multiple species.]. This antibody reacts with residues 130-136 in human myelin basic protein (21.5 kD and 18.5 kD molecular forms). It also recognizes primate, rabbit, sheep, goat, rat, and mouse myelin basic protein. ELISA titer = 1: 64,000.

form :

500 ug Protein G-purified antibody in PBS, pH 7.4.

storage stability :

These antibodies are stable for at least one (1) year at -20 degree C to -70 degree C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles

tested application :

Western Blot, Immunoassay, Immunohistochemistry

app notes :

This antibody may be used in immunoassays, immunohistochemistry, and Western Blot procedures for detection and/or quantitation of myelin basic protein.

other info1 :

Antigen: Purified human myelin basic protein.

other info2 :

Stabilizer: None. Preservatives: None. Available on request. Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.

products categories :

Neuroscience and Signal Transduction Antibodies

ncbi gi num :

1162922

ncbi acc num :

AAC41944.1

uniprot acc num :

P02686

ncbi mol weight :

33,117 Da

ncbi pathways :

MAPK Cascade Pathway (198834)

ncbi summary :

The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. [provided by RefSeq, Jul 2008]

uniprot summary :

MBP: The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non- classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T- cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. Homodimer. Isoform 3 exists as a homodimer. MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system. Belongs to the myelin basic protein family. 6 isoforms of the human protein are produced by alternative splicing. Protein type: Cytoskeletal. Chromosomal Location of Human Ortholog: 18q23. Cellular Component: compact myelin; internode region of axon; cell soma; plasma membrane; nucleus. Molecular Function: protein binding; structural constituent of myelin sheath; protease binding. Biological Process: response to mercury ion; myelination; synaptic transmission; central nervous system development; substantia nigra development; response to toxin; immune response; negative regulation of axonogenesis; axon ensheathment; response to progesterone stimulus; aging

size1 :

0.5 mg

price1 :

480 USD

more info or order :

MyBioSource product webpage