antibody

IGF-1 Receptor Monoclonal Antibody

MBS190274

0.1 mg

315 USD

monoclonal

mouse

nonconjugated

western blot, immunoprecipitation

Antibody

IGF-1 Receptor Monoclonal Antibody

IGF-1 receptor

Anti-IGF-1 receptor; IGF-1 Receptor

insulin-like growth factor 1 receptor; Insulin-like growth factor 1 receptor; insulin-like growth factor 1 receptor; IGF-1 receptor; IGF-I receptor; insulin-like growth factor I receptor; insulin-like growth factor receptor 1; insulin-like growth factor-I receptor; insulin-like growth factor 1 receptor beta subunit; Insulin-like growth factor I receptor

IGF1R; IGF1R; IGF1R

IGF1R_PIG

Monoclonal

IgG1

Mouse

304

Anti-IGF-1 receptor [Murine MAb recognizes human IGF-1 receptor; stimulates binding of IGF-1 and 2, stimulates cell growth.]. All three clones are specific for the human IGF-1 receptor. This product (3B7) stimulates binding of IGF-1 and -2; stimulates basal and IGF- 1 stimulated cell growth.

100 ug Protein G-purified antibody in PBS, pH 7.4

These antibodies are stable for at least one (1) year at -20 degree C to -70 degree C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles

Immunoblot, Immunoprecipitation

Use these antibodies in research studies to delineate signal transduction pathways specific for IGF's and for detecting IGF-1 receptors in crude samples. 35101 may be used to immunoprecipitate IGF-1 receptors. 35102 and 35103 can recognize the IGF-1 alpha subunit on immunoblots.

Antigen: Purified human placental IGF-1 receptors.

Stabilizer: None. Preservatives: None. Available on request. Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.

Growth Factors/Cytokines/Receptor Antibodies

Xiong et al. (1992) Proc Natl Acad Sci USA 89: 5356; Li et al. (1993) Biochem Biophys Res Commun 196: 92.

47523430

NP_999337.1

NM_214172.1

Q29000

34,615 Da

Adherens Junction Pathway 84482!!Adherens Junction Pathway 481!!Endocytosis Pathway 102268!!Endocytosis Pathway 102181!!Focal Adhesion Pathway 84479!!Focal Adhesion Pathway 478!!Glioma Pathway 84517!!Glioma Pathway 522!!Long-term Depression Pathway 84497!!Long-term Depression Pathway 497

Function: This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1. Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. Cofactor: Manganese. Subunit structure: Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chain carries the kinase domain. Forms a hybrid receptor with INSR, the hybrid is a tetramer consisting of 1 alpha chain and 1 beta chain of INSR and 1 alpha chain and 1 beta chain of IGF1R. Interacts with ARRB1 and ARRB2. Interacts with GRB10. Interacts with GNB2L1/RACK1. Subcellular location: Membrane; Single-pass type I membrane protein. Sequence similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.Contains 1 fibronectin type-III domain.Contains 1 protein kinase domain.

0.1 mg

315 USD