antibody

Human Transferrin Monoclonal Antibody

MBS190265

0.5 mg

300 USD

monoclonal

mouse

nonconjugated

Antibody

Human Transferrin Monoclonal Antibody

Transferrin

Anti-Transferrin; Transferrin

transferrin; Serotransferrin; serotransferrin; siderophilin; OTTHUMP00000197155; beta-1 metal-binding globulin; transferrin; Beta-1 metal-binding globulin; Siderophilin

TF; TF; PRO1557; PRO2086; DKFZp781D0156

TRFE_HUMAN

Monoclonal

IgG1

Mouse

698

Anti-Transferrin [N-terminus of human transferrin]. Reacts with the N-terminal domain of human transferrin, Kd = 2.85 x 10^-11 M. This antibody does not cross-react with mouse, rabbit, or bovine transferrin, nor with human lactoferrin.

500 ug Protein A-purified antibody in PBS, pH 7.4.

These antibodies are stable for at least one (1) year at -20 degree C to -70 degree C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles

ELISA, Immunoassay, Immunoflourescence

Antigen: Purified human transferrin from pooled human plasma.

Stabilizer: None. Preservatives: 0.1% sodium azide. Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.

Hormone and Serum Protein Antibodies

248648

AAB22049.1

P02787

77,064 Da

EPHB Forward Signaling Pathway (138047); Formation Of Platelet Plug Pathway (106029); HIF-1-alpha Transcription Factor Network Pathway (138045); Hemostasis Pathway (106028); Iron Uptake And Transport Pathway (187191); Mineral Absorption Pathway (212237); Mineral Absorption Pathway (212220); Platelet Activation Pathway (106034); Platelet Degranulation Pathway (106050); Response To Elevated Platelet Cytosolic Ca2+ Pathway (106048)

This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq]

TF: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. Defects in TF are the cause of atransferrinemia (ATRAF). Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia. Belongs to the transferrin family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 3q22.1. Cellular Component: extracellular space; recycling endosome; cell surface; endocytic vesicle; perinuclear region of cytoplasm; early endosome; cytoplasmic membrane-bound vesicle; late endosome; apical plasma membrane; basal plasma membrane; extracellular region; coated pit; endosome membrane; vesicle. Molecular Function: protein binding; ferric iron binding; ubiquitin protein ligase binding. Biological Process: retinal homeostasis; platelet activation; platelet degranulation; cellular iron ion homeostasis; transferrin transport; blood coagulation; transmembrane transport. Disease: Atransferrinemia

0.5 mg

300 USD