catalog number :
MBS190238
products full name :
Human Granulocyte Macrophage Colony Stimulating Factor Monoclonal Antibody
products short name :
Granulocyte Macrophage-Colony Stimulating Factor
products name syn :
Mouse Anti Human Granulocyte Macrophage-Colony Stimulating Factor; Granulocyte Macrophage-Colony Stimulating Factor
other names :
granulocyte-macrophage colony-stimulating factor; Granulocyte-macrophage colony-stimulating factor; granulocyte-macrophage colony-stimulating factor; CSF; molgramostin; sargramostim; OTTHUMP00000065962; granulocyte-macrophage colony stimulating factor; colony stimulating factor 2 (granulocyte-macrophage); Colony-stimulating factor; CSF; Molgramostin; Sargramostim
other gene names :
CSF2; CSF2; GMCSF; MGC131935; MGC138897; GMCSF
uniprot entry name :
CSF2_HUMAN
specificity :
Mouse Anti Human Granulocyte Macrophage-Colony Stimulating Factor [Mouse monoclonal antibody to human Granulocyte Macrophage-Colony Stimulating Factor]
storage stability :
Store lyophilized product at 4 degree C. After reconstitution, aliquot and store at -20 degree C. Stable 2 years lyophilized; one month in solution at 4 degree C.
tested application :
ELISA
other info1 :
Antigen: recombinant human GM-CSF
other info2 :
Stabilizer: None. Preservatives: None. Dilutions Instructions: Reconstitute with water. Mix gently, washing the sides of the vial. Wait 1 minute before use.
products categories :
Growth Factors/Cytokines/Receptor Antibodies
ncbi acc num :
NP_000749.2
ncbi gb acc num :
NM_000758.2
ncbi mol weight :
16,295 Da
ncbi pathways :
Amoebiasis Pathway 167324!!Amoebiasis Pathway 167191!!Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway 137993!!Calcium Signaling In The CD4+ TCR Pathway 137941!!Cytokine Signaling In Immune System Pathway 366171!!Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!Cytokines And Inflammatory Response Pathway 198794!!Fc Epsilon RI Signaling Pathway 83082!!Fc Epsilon RI Signaling Pathway 493
ncbi summary :
The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. [provided by RefSeq]
uniprot summary :
Function: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. Subunit structure: Monomer. Subcellular location: Secreted. Polymorphism: Variant Ile-117 may be a risk factor for atopic asthma. Pharmaceutical use: Available under the names Leukine (Immunex) and Leucomax (Novartis). Used in myeloid reconstitution following bone marrow transplant, bone marrow transplant engraftment failure or delay, mobilization and following transplantation of autologous peripheral blood progenitor cells, and following induction chemotherapy in older adults with acute myelogenous leukemia. Sequence similarities: Belongs to the GM-CSF family.