catalog number :
MBS190175
products full name :
Gonadotropin Releasing Hormone Monoclonal Antibody
products short name :
Gonadotropin Releasing Hormone
products name syn :
Anti-Gonadotropin Releasing Hormone; GnRH
other names :
gonadotropin-releasing hormone; Progonadoliberin-1; progonadoliberin-1; luliberin I; OTTHUMP00000225172; OTTHUMP00000225173; progonadoliberin I; GnRH-associated peptide 1; prolactin release-inhibiting factor; gonadotropin-releasing hormone 1 (leutinizing-releasing hormone); gonadotropin-releasing hormone 1 (luteinizing-releasing hormone); Progonadoliberin ICleaved into the following 2 chains:Gonadoliberin-1; Alternative name(s):; Gonadoliberin I; Gonadorelin; Gonadotropin-releasing hormone I; GnRH-I; Luliberin I; Luteinizing hormone-releasing hormone I; LH-RH IGnRH-associated peptide 1; Alternative name(s):; GnRH-associated peptide I
other gene names :
GNRH1; GNRH1; GRH; GNRH; LHRH; LNRH; GNRH; GRH; LHRH
uniprot entry name :
GON1_HUMAN
specificity :
Anti-Gonadotropin Releasing Hormone [Murine MAbs recognize human gonadotropin releasing hormone (4 clones). LP]
form :
1 ml ascites or 1 mg Protein G-purified antibody in PBS, pH 7.4.
storage stability :
These antibodies are stable for at least one (1) year at -20 degree to-70 degree C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.
tested application :
ELISA, Immunohistochemistry
app notes :
These antibodies may be used in ELISA, immunohistochemistry and RIA to detect and quantitate GnRH.
other info1 :
Antigen: Purified human gonadotropin releasing hormone. Activity: Ig mg/ml*: 17.1. ELISA Titer**: 1: 3,200. ng GnRH for 50% Displacement: 1.10. (Note: * Determined by radial immunodiffusion for several lots of ascites. **ELISA is an indirect assay against human GnRH on the solid phase. Titers represent endpoint dilutions that achieve absorbance values >= 0.1.)
other info2 :
Stabilizer: None. Preservatives: None. Available on request. Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.
products categories :
Hormone and Serum Protein Antibodies
products references :
Rajendren G and Gibson MJ (2001) J Neuroendocrinology 13: 270-274.
ncbi acc num :
CAA33285.1
ncbi mol weight :
10,380 Da
ncbi pathways :
Class A/1 (Rhodopsin-like Receptors) Pathway 106357!!G Alpha (q) Signalling Events Pathway 106043!!GPCR Downstream Signaling Pathway 119548!!GPCR Ligand Binding Pathway 161020!!GnRH Signaling Pathway 83091!!GnRH Signaling Pathway 502!!Hormone Ligand-binding Receptors Pathway 106369!!Nongenotropic Androgen Signaling Pathway 138048!!Signaling By GPCR Pathway 106356
ncbi summary :
The protein encoded by this gene is secreted and then cleaved to form the 10 aa luteinizing hormone-releasing hormone (LHRH), also known as gonadoliberin-1, and prolactin release-inhibiting factor, also known as GnRH-associated peptide 1. LHRH stimulates the release of luteinizing and follicle stimulating hormones, which are important for reproduction. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]
uniprot summary :
Function: Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones. Subcellular location: Secreted. Pharmaceutical use: Available under the names Factrel (Ayerst Labs), Lutrepulse or Lutrelef (Ferring Pharmaceuticals) and Relisorm (Serono). Used in evaluating hypothalamic-pituitary gonadotropic function. Sequence similarities: Belongs to the GnRH family.