catalog number :
MBS190166
products full name :
FK-506 Monoclonal Antibody
products short name :
FK-506
products name syn :
Anti-FK-506; FK-506
other names :
FK-506 binding protein
specificity :
Anti-FK-506 [Murine MAb recognizes conjugated and non-conjugated FK-506.]. This antibody recognizes conjugated and non-conjugated FK-506 (Kd=10-9 M).
form :
200 ug IgM in PBS, pH 7.4.
storage stability :
This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.
tested application :
ELISA, Western Blot
app notes :
This antibody may be used in ELISA and Western Blotting to detect FK-506.
other info1 :
Antigen: FK-506 conjugated to bovine serum albumin.
other info2 :
Stabilizer: None. Preservatives: 0.1% sodium azide. Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.
products categories :
Drug Antibodies
products description :
FK-506 is a novel macrolide with similar, but more potent, immunosuppressant activity than cyclosporine. FK-506 is used for primary or rescue immunosuppression in patients after solid organ transplantation. Clinically relevant side effects of FK-506 administration are nephrotoxicity, neurotoxicity, diabetes mellitus, and hypertension. Most of these side effects are related to blood levels of FK-506 rather than dosage. Therefore, therapeutic drug monitoring of FK-506 is a prerequisite for therapy. The whole blood target level range aimed for in clinical practice is 3.0-20.0 ng/ml and depends on the patient's liver function, the nature of organ transplantation, and the time after transplantation.
ncbi pathways :
Focal Adhesion Pathway (83067); Focal Adhesion Pathway (478); MAPK Signaling Pathway (83048); MAPK Signaling Pathway (456); Salmonella Infection Pathway (375172); Salmonella Infection Pathway (375149)