antibody

Estrogen Receptor- alpha Monoclonal Antibody

MBS190147

0.1 mL

410 USD

monoclonal

mouse

nonconjugated

western blot, immunoprecipitation

Antibody

Estrogen Receptor- alpha Monoclonal Antibody

Estrogen Receptor Alpha

Anti-Estrogen Receptor Alpha; Estrogen Receptor-alpha

estrogen receptor alpha; Putative uncharacterized protein; estrogen receptor; ER-alpha; OTTHUMP00000017718; OTTHUMP00000017719; estradiol receptor; estrogen receptor alpha delta 4 +49 isoform; nuclear receptor subfamily 3 group A member 1; estrogen receptor alpha delta 4*,5,6,7*/654 isoform; estrogen receptor alpha delta 3*,4,5,6,7*/819-2 isoform; estrogen receptor 1

ESR1; ER; ESR; Era; ESRA; NR3A1; DKFZp686N23123

A0A4R1_HUMAN

Monoclonal

IgG1 kappa

Mouse

20

Anti-Estrogen Receptor Alpha [Murine MAb to fusion protein corresponding to aa 1-190 of human estrogen receptor-alpha, a member of the steroid family of nuclear receptors.]. This antibody recognizes human ER- alpha , a 65 kD protein and a member of the steroid family of nuclear receptors. ER- alpha is a ligand-activated transcription factor that, when bound to estrogen, induces a conformational change that allows dimerization and binding to estrogen response element sequences. When bound to DNA, ER- alpha can positively or negatively regulate gene transcription.

100 ug Protein G-purified antibody in PBS, pH 7.4

This antibody is stable for at least one (1) year at -70 degree C. Avoid multiple freeze thaw cycles.

Immunoblot, Immunoprecipitation

Immunoblotting: use at 1-5 ug/ml. Immunoprecipitation: use at 1-5 ug/ml. Positive controls: MCF-7 cells andrecombinant protein.

Antigen: 6-His fusion proteincontaining the region encoding aa 1-190of human estrogen receptor- alpha (ER- alpha ) expressed in E. coli.

Stabilizer: None. Preservatives: None. Available on request. Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.

Cancer Research Products

5821726

AAD52984.1

P03372

2,203 Da

Androgen Receptor Signaling Pathway (198806); Endocrine And Other Factor-regulated Calcium Reabsorption Pathway (213307); Endocrine And Other Factor-regulated Calcium Reabsorption Pathway (213276); Estrogen Signaling Pathway (198863); FOXA1 Transcription Factor Network Pathway (137979); FOXM1 Transcription Factor Network Pathway (137935); Gene Expression Pathway (105937); Generic Transcription Pathway (105938); LKB1 Signaling Events Pathway (137957); Nuclear Receptor Transcription Pathway (105979)

This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters. [provided by RefSeq]

0.1 mL

410 USD