Cardiac Troponin I Monoclonal Antibody | MyBioSource MBS190081 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Cardiac Troponin I Monoclonal Antibody

catalog :

MBS190081

quantity :

0.1 mg

price :

240 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human

application :

western blot

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS190081

products type :

Antibody

products full name :

Cardiac Troponin I Monoclonal Antibody

products short name :

Cardiac Troponin I

products name syn :

Anti-Cardiac Troponin I; Cardiac Troponin I

other names :

cardiac troponin I; Troponin I, cardiac muscle; troponin I, cardiac muscle; troponin I type 3 (cardiac); Cardiac troponin I

other gene names :

TNNI3; TNNI3; CMH7; RCM1; cTnI; CMD2A; TNNC1; CMD1FF; MGC116817; TNNC1

uniprot entry name :

TNNI3_HUMAN

clonality :

Monoclonal

isotype :

IgG1

host :

Mouse

sequence length :

210

specificity :

Anti-Cardiac Troponin I [Murine MAbs recognize human cardiac troponin I and do not cross-react with human skeletal troponin (2 clones).]

form :

100 ug Protein A-purified antibody in PBS, pH 7.4.

storage stability :

These antibodies are stable for at least one (1) year at -20 degree C to -70 degree C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles

tested application :

Western Blot, Immunoassay

app notes :

These antibodies may be used in immunoassays and Western Blots to detect and quantitate human cardiac troponin I. They may also be used to affinity purify cardiac troponin I.

other info1 :

Antigen: Purified human cardiac troponin I. Activity and Specificity: These antibodies react specifically with human cardiac troponin I. There is no cross-reactivity with human skeletal troponin I. ELISA titers > 1: 1,000,000.

other info2 :

Stabilizer: None. Preservatives: 0.1% sodium azide. Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.

products categories :

Hormone and Serum Protein Antibodies

ncbi gi num :

1524066

ncbi acc num :

CAA62301.1

uniprot acc num :

P19429

ncbi mol weight :

24,008 Da

ncbi pathways :

Cardiac Muscle Contraction Pathway 93344!!Cardiac Muscle Contraction Pathway 93992!!Dilated Cardiomyopathy Pathway 121494!!Dilated Cardiomyopathy Pathway 121285!!Hypertrophic Cardiomyopathy (HCM) Pathway 114229!!Hypertrophic Cardiomyopathy (HCM) Pathway 106591!!Muscle Contraction Pathway 106261!!Striated Muscle Contraction Pathway 106262!!Striated Muscle Contraction Pathway 198903

ncbi summary :

Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq]

uniprot summary :

Function: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Subunit structure: Binds to actin and tropomyosin. Interacts with TRIM63. Ref.7. Involvement in disease: Defects in TNNI3 are the cause of cardiomyopathy familial hypertrophic type 7 (CMH7) [. MIM:613690]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. Ref.10 Ref.11 Ref.13 Ref.15 Ref.17Defects in TNNI3 are the cause of cardiomyopathy familial restrictive type 1 (RCM1) [. MIM:115210]. RCM1 is an heart muscle disorder characterized by impaired filling of the ventricles with reduced diastolic volume, in the presence of normal or near normal wall thickness and systolic function.Defects in TNNI3 are the cause of cardiomyopathy dilated type 2A (CMD2A) [. MIM:611880]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Ref.16Defects in TNNI3 are the cause of cardiomyopathy dilated type 1FF (CMD1FF) [. MIM:613286]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Sequence similarities: Belongs to the troponin I family.

size :

0.1 mg

price :

240 USD

more info or order :

MyBioSource product webpage