Bcl-3 Monoclonal Antibody | MyBioSource MBS190067 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Bcl-3 Monoclonal Antibody

catalog :

MBS190067

quantity :

0.1 mg

price :

320 USD

clonality :

monoclonal

host :

hamsters

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS190067

products type :

Antibody

products full name :

Bcl-3 Monoclonal Antibody

products short name :

Bcl-3

products name syn :

Bcl-3

other names :

B-cell lymphoma 3 protein; B-cell lymphoma 3 protein; B-cell lymphoma 3 protein; BCL-3; OTTHUMP00000200151; OTTHUMP00000200152; proto-oncogene BCL3; B-cell leukemia/lymphoma 3; B-cell lymphoma 3-encoded protein; chronic lymphatic leukemia protein; B-cell CLL/lymphoma 3; Proto-oncogene BCL3

other gene names :

BCL3; BCL3; BCL4; D19S37; BCL4; D19S37

uniprot entry name :

BCL3_HUMAN

clonality :

Monoclonal

host :

Hamster

specificity :

Bcl-3 [Human and mouse Bcl-3]. This antibody recognizes human and mouse Bcl-3.

form :

100 ug IgG in PBS, pH 7.4, purified by Protein G affinity chromatography.

storage stability :

This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.

tested application :

ELISA, Immunoblot

app notes :

Immunoblotting: use at 2 ug/ml. A band of approx. 46-52 kDa is detected. ELISA: end-user should determine optimal concentration for each sample. Positive control: Jurkat T cell lysate.

other info1 :

Immunogen: Recombinant mouse Bcl-3-6His.

other info2 :

Stabilizer: None. Preservatives: None. Available on request. Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.

products categories :

Apoptosis Antibodies

products description :

The gene encoding Bcl-3 was first identified as the gene altered in some cases of chronic B cell lymphocytic leukemia and was later found to belong to the I kappa B subfamily of inhibitors of NF kappa B transcription factors. Bcl-3 does not have DNA-binding activity, but it interacts with NF kappa B1 and NF kappa B2 which, when bound to DNA, repress gene transcription. Therefore, Bcl-3 may promote gene expression that is repressed by members of the NF kappa B family. Bcl-3 RNA is highly expressed in spleen and liver with lower levels of expression in heart, skeletal muscle, lung, kidney, and testes.

products references :

Mitchell, TC et al. (2001) Nature Immunology 2: 397-402. Watanabe, N et al. (1997) EMBO J 16: 3609-20. Nolan, GP et al. (1993) Molecular and Cellular Biology 13: 3557-66.

ncbi gi num :

164664508

ncbi acc num :

NP_005169.2

ncbi gb acc num :

NM_005178.4

uniprot acc num :

P20749

ncbi mol weight :

47,584 Da

ncbi pathways :

Atypical NF-kappaB Pathway (137946); TNF-alpha/NF-kB Signaling Pathway (198884)

ncbi summary :

This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B. [provided by RefSeq]

uniprot summary :

Function: Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation. By similarity. Ref.4. Subunit structure: Component of a complex consisting of the NF-kappa-B p52-p52 homodimer and BCL3. Component of a complex consisting of the NF-kappa-B p50-p50 homodimer and BCL3. Interacts with N4BP2, COPS5 and PIR. Interacts with CYLD. By similarity. Ref.6 Ref.7. Subcellular location: Nucleus. Cytoplasm. By similarity. Cytoplasm perinuclear region. By similarity. Note: Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation. Post-translational modification: Polyubiquitinated. Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains. Deubiquitination by CYLD prevents nuclear accumulation. By similarity.Activated by phosphorylation. Involvement in disease: Note=A chromosomal aberration involving BCL3 may be a cause of B-cell chronic lymphocytic leukemia (B-CLL). Translocation t(14;19)(q32;q13.1) with immunoglobulin gene regions. Sequence similarities: Contains 7 ANK repeats. Caution: It is uncertain whether Met-1 or Met-9 is the initiator. Sequence caution: The sequence AAA51815.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAA51816.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAH64993.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

size1 :

0.1 mg

price1 :

320 USD

more info or order :

MyBioSource product webpage