antibody

Alpha-1-Antitrypsin Monoclonal Antibody

MBS190009

1 mg

370 USD

monoclonal

mouse

nonconjugated

Antibody

Alpha-1-Antitrypsin Monoclonal Antibody

Alpha-1-antitrypsin

Anti-Alpha-1-antitrypsin; Alpha-1- Anti-Trypsin

alpha-1-antitrypsin; Alpha-1-antitrypsin; Alpha-1 protease inhibitor; Alpha-1-antiproteinase; Serpin A1

SERPINA1; AAT; PI

A1AT_HUMAN

Monoclonal

IgG2a

Mouse

418

Anti-Alpha-1-antitrypsin [Human serum alpha-1-antitrypsin (4 clones). LP]. These antibodies specifically recognize alpha-1-antitrypsin.They do not crossreact with alpha-1-antichymotrypsin.

1 ml ascites or 1 mg Protein G-purified antibody in PBS, pH 7.4

These antibodies are stable for at least one (1) year at -20 degree C to -70 degree C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.

Immunoassay

These antibodies may be used in immunoassays to detect and quantitate alpha-1-antitrypsin. Other applications are under investigation.

Antigen: Purified human serum alpha- 1-antitrypsin. Activity: Ig mg/ml* :22.0. ELISA Titer**:1:204,800. (Note: * Determined by radial immunodiffusion for several lots of ascites. **ELISA is an indirect assay against alpha-1-antitrypsin on the solid phase. Titers represent endpoint dilutions that achieve absorbance values >= 0.1)

Stabilizer: None. Preservatives: None. Available on request. Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.

Enzyme and Enzyme Inhibitor Antibodies

151302818

CAJ15161.1

P01009

46,737 Da

Focal Adhesion Pathway (83067); Focal Adhesion Pathway (478); MAPK Signaling Pathway (83048); MAPK Signaling Pathway (456); Salmonella Infection Pathway (375172); Salmonella Infection Pathway (375149)

The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

SERPINA1: Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin. Defects in SERPINA1 are the cause of alpha-1-antitrypsin deficiency (A1ATD). A disorder whose most common manifestation is emphysema, which becomes evident by the third to fourth decade. A less common manifestation of the deficiency is liver disease, which occurs in children and adults, and may result in cirrhosis and liver failure. Environmental factors, particularly cigarette smoking, greatly increase the risk of emphysema at an earlier age. Belongs to the serpin family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Inhibitor; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 14q32.1. Cellular Component: Golgi apparatus; proteinaceous extracellular matrix; extracellular space; endoplasmic reticulum; extracellular region. Molecular Function: serine-type endopeptidase inhibitor activity; identical protein binding; protein binding; protease binding; glycoprotein binding. Biological Process: platelet activation; response to chromate; platelet degranulation; response to triglyceride; response to cytokine stimulus; response to lead ion; acute-phase response; response to methanol; response to hypoxia; response to lipopolysaccharide; blood coagulation; response to estradiol stimulus. Disease: Alpha-1-antitrypsin Deficiency; Pulmonary Disease, Chronic Obstructive

1 mg

370 USD