Anti-human CD38 Antibody APC Conjugated, Flow Validated | MyBioSource MBS178890 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-human CD38 Antibody APC Conjugated, Flow Validated

catalog :

MBS178890

quantity :

25 Tests

price :

160 USD

clonality :

monoclonal

host :

mouse

conjugate :

APC

clone name :

[OKT10]

reactivity :

human

application :

flow cytometry, FACS

more info or order :

MyBioSource product webpage

image

image 1 :

Monocytes gated PBMCs stained with APC conjugated anti-human CD38 (cloneOKT10) (Red Histogram). Monocytes gated PBMCs stained with APC conjugated MOPC-31C IgG1 isotype control (Blue Histogram).

product information

catalog number :

MBS178890

products type :

Antibody

products full name :

Anti-human CD38 Antibody APC Conjugated, Flow Validated

products short name :

[CD38]

products name syn :

[ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; 3.2.2.6; 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase; 2.4.99.20; 2'-phospho-cyclic-ADP-ribose transferase; ADP-ribosyl cyclase 1; ADPRC 1; Cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; T10; CD38; CD38]

other names :

[ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; CD38 molecule; 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase (EC:2.4.99.20); 2'-phospho-cyclic-ADP-ribose transferase; ADP-ribosyl cyclase 1; ADPRC 1; Cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; T10; CD_antigen: CD38]

products gene name :

[CD38]

other gene names :

[CD38; CD38; ADPRC1; ADPRC 1; ADPRC 1; cADPr hydrolase 1]

clonality :

Monoclonal

isotype :

IgG1, k

clone :

[OKT10]

host :

Mouse

reactivity :

Human

sequence length :

122

purity :

Protein A purified

form :

Liquid; PBS, pH7.2, 0.09% NaN3 and 0.2% (w/v) BSA

concentration :

0.5-1.0mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

storage stability :

Store at 4°C and protect from prolonged exposure to light. Do not freeze.

tested application :

Flow Cytometry (FC/FACS)

app notes :

Each lot of this antibody has been pre-titrated and tested by flow cytometric analysis of human PBMCs such that 5 ul of this product is sufficient for staining 1 million cells in a 100 ul staining volume or 100 ul whole blood. It is recommended that antibody reactivity be empirically titrated for optimal performance in the application of interest. User needs to optimize the dilution ration for this antibody.

image1 heading :

Testing Data

other info2 :

Conjugate: APC

products categories :

Immunology; Adaptive Immunity; B Cells; Stem Cells; Hematopoietic Progenitors; Hematopoietic Stem Cells; Human Lineage Negative; Surface Molecules; Lymphoid; B Lymphocytic Lineage; T Lymphocytic Lineage; nk cell lineage; Myeloid; monocytic lineage; Immuno

products description :

Description: Mouse Monoclonal Anti-human CD38 APC Conjugated, designed for Flow Cytometry and validated by Flow Cytometry using Human cells. Introduction: CD38 is a type II transmembrane glycoprotein of 45 kDa with a protein core of 35 kDa. The CD38 antigen is expressed on essentially all pre-B lymphocytes, plasma cells, and thymocytes. It is also present on activated T lymphocytes, natural killer (NK) lymphocytes, myeloblasts, and erythroblasts. The antigen is expressed during the early stages of T- and B-lymphocyte differentiation, is lost during the intermediate stages of maturation, and then reappears during the final stages of maturation. The CD38 antigen is expressed on 90% of CD34+ cells, and is not expressed on pluripotent stem cells. Coexpression of CD38 antigen on CD34+ cells indicates lineage commitment of those cells. CD38 is a counter-receptor of CD31. It is also expressed in T- and B-acute lymphoblastic leukemia (ALL), Burkitts lymphoma, multiple myeloma, acute myeloid leukemia (AML), and chronic lymphocytic leukemia (CLL). The OKT10 antibody directed against human CD38 antigen. This antibody is routinely tested by flow cytometric analysis. Flow cytometry and other applications were tested during antibody development by CapricoBio or are reported in the literature.

ncbi gi num :

38454326

ncbi acc num :

NP_001766.2

ncbi gb acc num :

NM_001775.3

uniprot acc num :

P28907

ncbi pathways :

Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Epstein-Barr Virus Infection Pathway (585562); Epstein-Barr Virus Infection Pathway (587115); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489); Metabolic Pathways (132956); Nicotinate And Nicotinamide Metabolism Pathway (83014); Nicotinate And Nicotinamide Metabolism Pathway (400); Oxytocin Signaling Pathway (952859)

ncbi summary :

The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

uniprot summary :

Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.

size1 :

25 Tests

price1 :

160 USD

size2 :

100 Tests

price2 :

255

size3 :

200 Tests

price3 :

400

more info or order :

MyBioSource product webpage