Anti-AGTR1 Antibody | MyBioSource MBS178133 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-AGTR1 Antibody

catalog :

MBS178133

quantity :

0.1 mg

price :

315 USD

clonality :

polyclonal

host :

unidentified

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

image

image 1 :

Anti- AGTR1 Picoband antibody, MBS178133, Western blotting. All lanes: Anti AGTR1 (MBS178133) at 0.5ug/ml. Lane 1: HELA Whole Cell Lysate at 40ug. Lane 2: HEPA Whole Cell Lysate at 40ug. Predicted bind size: 47KD. Observed bind size: 47KD

image 2 :

Anti- AGTR1 Picoband antibody, MBS178133, IHC(P). IHC(P): Human Mammary Cancer Tissue

product information

catalog number :

MBS178133

products type :

Antibody

products full name :

Anti-AGTR1 Antibody

products short name :

[AGTR1]

products name syn :

[Type-1 angiotensin II receptor; AG2S; Agtr 1; Agtr1; AGTR1_HUMAN; Agtr1a; AGTR1B; Ang II; Angiotensin II receptor type 1; Angiotensin II type-1 receptor; Angiotensin receptor 1; Angiotensin receptor 1B; AT 1B; AT 1r; AT1; At1a; AT1AR; AT1B; AT1BR; AT1R; AT2R1; AT2R1A; AT2R1B; HAT1R; Type 1 angiotensin II receptor; Type 1B angiotensin II receptor; Type-1 angiotensin II receptor; angiotensin II receptor, type 1]

other names :

[type-1 angiotensin II receptor isoform 1; Type-1 angiotensin II receptor; type-1 angiotensin II receptor; angiotensin II receptor type 1; AT1AR; AT1BR; Angiotensin II type-1 receptor; AT1]

products gene name :

[AGTR1]

other gene names :

[AGTR1; AGTR1; AT1; AG2S; AT1B; AT1R; AT1AR; AT1BR; AT2R1; HAT1R; AGTR1B; AGTR1A; AGTR1B; AT2R1; AT2R1B; AT1]

uniprot entry name :

AGTR1_HUMAN

clonality :

Polyclonal

host :

unknown

reactivity :

Human, Mouse

sequence length :

359

specificity :

No cross reactivity with other protiens.

purity :

Immunogen Affinity Purified

form :

Lyophilized

storage stability :

At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquoted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.

tested application :

Western Blot (WB), Immunohistochemistry (IHC) Paraffin

app notes :

Western Blot. Concentration: 0.1-0.5ug/ml. Tested Species: Hu, Ms. Immunohistochemistry (IHC) Paraffin: . Concentration: 0.5-1ug/ml. Tested Species: Hu . Antigen Retrieval: By Heat. Tested Species: In-house tested species with positive results. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions shold be determined by end users.

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

other info1 :

Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3. Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human AGTR1 (1-28aa MILNSSTEDGIKRIQDDCPKAGRHNYIF), different from the related mouse and rat sequences by one amino acid. Ig Type: Rabbit IgG

other info2 :

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

products description :

Description: Rabbit IgG polyclonal antibody for Type-1 angiotensin II receptor(AGTR1) detection. Tested with WB, IHC-P in Human;Mouse. Background: AGTR1 is known as Angiotensin II Type 1 Receptor. Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. And it acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. Moreover, this gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene.

products references :

1. "Entrez Gene: AGTR1 angiotensin II receptor, type 1". 2. Catt KJ, Mendelsohn FA, Millan MA, Aguilera G (1984). "The role of angiotensin II receptors in vascular regulation". J. Cardiovasc. Pharmacol. 6(Suppl 4): S575-86. 3. Higuchi S, Ohtsu H, Suzuki H, Shirai H, Frank GD, Eguchi S (2007). "Angiotensin II signal transduction through the AT1 receptor: novel insights into mechanisms and pathophysiology". Clin. Sci. 112 (8): 417-28.

ncbi gi num :

4501997

ncbi acc num :

NP_000676.1

ncbi gb acc num :

NM_000685.4

uniprot acc num :

P30556

ncbi pathways :

ACE Inhibitor Pathway (198763); AGE-RAGE Signaling Pathway In Diabetic Complications (1319988); AGE-RAGE Signaling Pathway In Diabetic Complications (1319775); Adrenergic Signaling In Cardiomyocytes Pathway (908257); Adrenergic Signaling In Cardiomyocytes Pathway (909696); Aldosterone Synthesis And Secretion Pathway (1272485); Aldosterone Synthesis And Secretion Pathway (1285075); Angiopoietin Receptor Tie2-mediated Signaling Pathway (137917); Arf6 Signaling Events Pathway (138034); Calcium Signaling Pathway (83050)

ncbi summary :

Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Jul 2012]

uniprot summary :

AT1: receptor for angiotensin II. Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. Mediates the major cardiovascular effects of angiotensin II. May play role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Protein type: Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 3q24. Cellular Component: integral to membrane; integral to plasma membrane; intracellular; plasma membrane. Molecular Function: angiotensin type I receptor activity; angiotensin type II receptor activity; bradykinin receptor binding; protein binding; protein heterodimerization activity. Biological Process: calcium-mediated signaling; elevation of cytosolic calcium ion concentration; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); kidney development; positive regulation of cellular protein metabolic process; positive regulation of inflammatory response; positive regulation of NAD(P)H oxidase activity; positive regulation of phospholipase A2 activity; regulation of cell growth; regulation of cell proliferation; regulation of inflammatory response; regulation of systemic arterial blood pressure by renin-angiotensin; regulation of vasoconstriction; regulation of vasodilation; renin-angiotensin regulation of aldosterone production; renin-angiotensin regulation of blood vessel size; Rho protein signal transduction. Disease: Hypertension, Essential; Renal Tubular Dysgenesis

size1 :

0.1 mg

price1 :

315 USD

more info or order :

MyBioSource product webpage