Anti-MCSF Antibody | MyBioSource MBS177804 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-MCSF Antibody

catalog :

MBS177804

quantity :

0.1 mg

price :

315 USD

clonality :

polyclonal

host :

unidentified

conjugate :

nonconjugated

reactivity :

mouse, rat

application :

ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Anti- MCSF Picoband antibody, MBS177804, IHC(P). IHC(P): Mouse Spleen Tissue

image 2 :

Anti- MCSF Picoband antibody, MBS177804, IHC(P). IHC(P): Rat Spleen Tissue

product information

catalog number :

MBS177804

products type :

Antibody

products full name :

Anti-MCSF Antibody

products short name :

[MCSF]

products name syn :

[Macrophage colony-stimulating factor 1; Colony stimulating factor 1 (macrophage); Colony stimulating factor 1; Colony stimulating factor macrophage specific; CSF 1; CSF-1; CSF1; CSF1_HUMAN; Csfm; Lanimostim; M CSF; M-CSF; Macrophage Colony Stimulating Factor 1; Macrophage colony stimulating factor; MCSF; MGC31930; Processed macrophage colony-stimulating factor 1; colony stimulating factor 1 (macrophage)]

other names :

[macrophage colony-stimulating factor 1 isoform 2; Macrophage colony-stimulating factor 1; macrophage colony-stimulating factor 1; colony stimulating factor 1 (macrophage)]

products gene name :

[MCSF]

other gene names :

[Csf1; Csf1; op; Csfm; MCSF; C87615; Csfm; CSF-1; MCSF]

uniprot entry name :

CSF1_MOUSE

clonality :

Polyclonal

host :

unknown

reactivity :

Mouse, Rat

sequence length :

257

specificity :

No cross reactivity with other proteins.

purity :

Immunogen Affinity Purified

form :

Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

storage stability :

At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquoted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.

tested application :

Immunohistochemistry (IHC) Paraffin-embedded Section, ELISA (EIA)

app notes :

Immunohistochemistry (Paraffin-embedded Section). Concentration: 0.5-1 ug/ml. Tested Species: Ms, Rat. Antigen Retrieval: By Heat. ELISA. Concentration: 0.1-0.5 ug/ml. Tested Species: Ms. Tested Species: In-house tested with positive results. By Heat: Boiling the paraffin sections in 10 mM citrate buffer,pH 6.0 for 20 mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

image1 heading :

Immunohistochemistry (IHC)

image2 heading :

Immunohistochemistry (IHC)

other info1 :

Immunogen: E Coli-derived mouse MCSF recombinant protein (Position: K33-E262). Mouse MCSF shares 80.9 % and 88.6% amino acid (aa) sequence identity with human and rat MCSF, respectively. Ig Type: Rabbit IgG

other info2 :

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

products description :

Description: Rabbit IgG polyclonal antibody for Macrophage colony-stimulating factor 1(CSF1) detection. Tested with IHC-P, ELISA in Mouse;Rat. Background: M-CSF (or CSF-1) is a hematopoietic growth factor that is involved in the proliferation, differentiation, and survival ofmonocytes, macrophages, and bone marrow progenitor cells. M-CSF affects macrophages and monocytes in several ways, including stimulating increased phagocytic and chemotactic activity, and increased tumour cell cytotoxicity. The role of M-CSF is not only restricted to the monocyte/macrophage cell lineage. By interacting with its membrane receptor (CSF1R or M-CSF-R encoded by the c-fms proto-oncogene), M-CSF also modulates the proliferation of earlier hematopoietic progenitors and influence numerous physiological processes involved in immunology, metabolism, fertility and pregnancy.

products references :

1. Fixe P, Praloran V (June 1997)."Macrophage colony-stimulating-factor (M-CSF or CSF-1) and its receptor: structure-function relationships". Eur. Cytokine Netw. 8 (2): 125-36. 2. Nemunaitis J (April 1993). "Macrophage function activating cytokines: potential clinical application". Crit. Rev. Oncol. Hematol. 14 (2): 153-71. 3. Stanley ER, Berg KL, Einstein DB, Lee PS, Pixley FJ, Wang Y, Yeung YG (January 1997). "Biology and action of colony--stimulating factor-1". Mol. Reprod. Dev. 46(1): 4-10.

ncbi gi num :

166064046

ncbi acc num :

NP_001107001.1

ncbi gb acc num :

NM_001113529.1

uniprot acc num :

P07141

ncbi pathways :

Cytokine-cytokine Receptor Interaction Pathway (83248); Cytokine-cytokine Receptor Interaction Pathway (460); Cytokines And Inflammatory Response (BioCarta) Pathway (198283); Hematopoietic Cell Lineage Pathway (83275); Hematopoietic Cell Lineage Pathway (489); Osteoclast Differentiation Pathway (193149); Osteoclast Differentiation Pathway (193096); PI3K-Akt Signaling Pathway (692242); PI3K-Akt Signaling Pathway (692979); Rap1 Signaling Pathway (869018)

uniprot summary :

M-CSF: Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance. Aberrant expression of CSF1 or CSF1R can promote cancer cell proliferation, invasion and formation of metastases. Overexpression of CSF1 or CSF1R is observed in a significant percentage of breast, ovarian, prostate, and endometrial cancers. Aberrant expression of CSF1 or CSF1R may play a role in inflammatory diseases, such as rheumatoid arthritis, glomerulonephritis, atherosclerosis, and allograft rejection. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Cytokine; Membrane protein, integral. Cellular Component: extracellular region; extracellular space; integral to membrane; membrane; perinuclear region of cytoplasm; plasma membrane. Molecular Function: cytokine activity; growth factor activity; macrophage colony stimulating factor receptor binding; protein binding; protein homodimerization activity. Biological Process: cell proliferation; homeostasis of number of cells within a tissue; immune system process; inflammatory response; innate immune response; macrophage differentiation; odontogenesis; ossification; osteoclast differentiation; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of cell-matrix adhesion; positive regulation of cellular protein metabolic process; positive regulation of macrophage differentiation; positive regulation of monocyte differentiation; positive regulation of mononuclear cell proliferation; positive regulation of multicellular organism growth; positive regulation of odontogenesis of dentine-containing teeth; positive regulation of osteoclast differentiation; positive regulation of protein kinase activity; positive regulation of Ras protein signal transduction; regulation of ossification; reproductive developmental process; transmembrane receptor protein tyrosine kinase signaling pathway

size1 :

0.1 mg

price1 :

315 USD

more info or order :

MyBioSource product webpage