Anti-FES antibody | MyBioSource MBS177028 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-FES antibody

catalog :

MBS177028

quantity :

0.1 mg

price :

245 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS177028

products type :

Antibody

products full name :

Anti-FES antibody

products short name :

FES

products name syn :

Tyrosine-protein kinase Fes/Fps; feline sarcoma oncogene; c-fes/fps protein antibody; cFES antibody; feline sarcoma(Snyder-Theilen) viral(v-fes)/Fujinami antibody; Feline sarcoma oncogene antibody; fes antibody; FES_HUMAN antibody; FPS antibody; Oncogene FES antibody; Oncogene FES feline sarcoma virus antibody; Proto oncogene tyrosine protein kinase Fes/Fps antibody; Proto-oncogene c-Fes antibody; Proto-oncogene c-Fps antibody; proto-oncogene tyrosine-protein kinase Fes/Fps antibody; Tyrosine-protein kinase Fes/Fps antibody

other names :

Tyrosine-protein kinase Fes/Fps; Tyrosine-protein kinase Fes/Fps; tyrosine-protein kinase Fes/Fps; p93c-fes; proto-oncogene c-Fes; proto-oncogene c-Fps; feline sarcoma oncogene; Oncogene FES, feline sarcoma virus; proto-oncogene tyrosine-protein kinase Fes/Fps; feline sarcoma/Fujinami avian sarcoma oncogene homolog; feline sarcoma (Snyder-Theilen) viral (v-fes)/Fujinami avian sarcoma (PRCII) viral (v-fps) oncogene homolog; FES proto-oncogene, tyrosine kinase; Feline sarcoma/Fujinami avian sarcoma oncogene homolog; Proto-oncogene c-Fes; Proto-oncogene c-Fps; p93c-fes

products gene name :

FES

other gene names :

FES; FES; FPS; FPS

uniprot entry name :

FES_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

822

specificity :

No cross reactivity with other proteins.

purity :

Immunogen affinity purified.

form :

Lyophilized

storage stability :

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

tested application :

Western Blot (WB)

app notes :

Wester Blot: . Concentration: 0.1-0.5ug/ml. Tested Species: Hu. Predicted Species: Ms, Rat. Antigen Retrieval: n/a. Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determine by end users.

other info1 :

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human FES (644-663aa FLTFLRTEGARLRVKTLLQM), identical to the related mouse and rat sequences.

other info2 :

Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

products description :

Description: Rabbit IgG polyclonal antibody for Tyrosine-protein kinase Fes/Fps(FES) detection. Tested with WB in Human, Mouse, Rat. Background: FES(feline sarcoma oncogene) is an enzyme that in humans is encoded by the FES gene, also known as Proto-oncogene tyrosine-protein kinase Fes/Fps, Feline sarcoma/Fujinami avian sarcoma oncogene homolog, Proto-oncogene c-Fes, Proto-oncogene c-Fps, p93c-fes c-fes/fps protein, FPS, Oncogene FES, feline sarcoma virus, FPS. This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. Non-onc intervening sequences were present in the human counterpart. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia, but it is also involved in normal hematopoiesis. A truncated transcript has been identified that is generated utilizing a start site in one of the far downstream exons but a protein product associated with this transcript has not been identified.

ncbi gi num :

115502390

ncbi acc num :

P07332.3

uniprot acc num :

P07332

ncbi mol weight :

85,466 Da

ncbi pathways :

Angiopoietin Receptor Tie2-mediated Signaling Pathway (137917); Axon Guidance Pathway (83065); Axon Guidance Pathway (476); Axon Guidance Pathway (105688); CRMPs In Sema3A Signaling Pathway (119525); Developmental Biology Pathway (477129); IL-3 Signaling Pathway (198881); IL-4 Signaling Pathway (198760); IL-6 Signaling Pathway (198864); IL4-mediated Signaling Events Pathway (137933)

ncbi summary :

This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms.[provided by RefSeq, Jan 2009]

uniprot summary :

Fes: a non-receptor tyrosine kinase of the Fer family. Appears to be involved in normal hematopoiesis as well as the development of acute promyelocytic leukemia. Contains one SH2 and one FCH domain. Four LOF point mutations seen in colorectal cancer. Orthologous to v-fes from feline leukemia virus and v-fps from avian transforming virus. Mutant forms are angiogenic. Promotes survival during differentiation, and may act both to promote and inhibit tumors. May be disrupted in the t(15q+;17q-) found in acute promyelocytic leukemia, but the breakpoint does not occur within the gene. Protein type: EC 2.7.10.2; Kinase, protein; Protein kinase, tyrosine (non-receptor); Protein kinase, TK; Oncoprotein; Tumor suppressor; TK group; Fer family. Chromosomal Location of Human Ortholog: 15q26.1. Cellular Component: microtubule cytoskeleton; Golgi apparatus; extrinsic to internal side of plasma membrane; focal adhesion; cytoplasmic membrane-bound vesicle; cytoplasm; cytoplasmic vesicle; cytosol. Molecular Function: protein binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; phosphoinositide binding; ATP binding. Biological Process: regulation of mast cell degranulation; epidermal growth factor receptor signaling pathway; regulation of cell adhesion; axon guidance; cell migration; peptidyl-tyrosine phosphorylation; positive regulation of myeloid cell differentiation; protein amino acid autophosphorylation; multicellular organismal development; positive regulation of microtubule polymerization; chemotaxis; protein amino acid phosphorylation; regulation of cell proliferation; cell proliferation; regulation of cell shape; regulation of cell differentiation; innate immune response

size1 :

0.1 mg

price1 :

245 USD

more info or order :

MyBioSource product webpage